CAPriCORN Current Studies

PMI

Precision Medicine Initiative (PMI)

 Status: Recruitment

This research initiative is a groundbreaking approach to disease prevention and treatment based on individual differences in environment, genes, and lifestyle. The goal of this study is to engage a group of 1 million research participants who will share biological samples, genetic data and diet/lifestyle information, all linked to their electronic health records. This data will allow researchers to develop more precise treatments for many diseases and health conditions.

www.joinallofus.org

Rush principal investigator: Raj C. Shah, MD

 

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)

Status: Recruitment

PREVENTABLE is one of the largest research studies in older adults. We aim to learn if taking a statin, a commonly used drug to lower cholesterol, could help older adults live well for longer by preventing dementia, disability, or heart disease. The benefits of taking statins for older adults without heart disease are not fully understood. Results from PREVENTABLE will help us learn if taking a statin is helpful for older adults.

www.preventabletrial.org

Rush principal investigator: Raj C. Shah, MDADAPTABLE logo

Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE)

Status: Data Analysis

The purpose of ADAPTABLE is to compare the effectiveness of two daily doses of aspirin widely used to prevent heart attacks and strokes in individuals living with heart disease.  What we will learn from the ADAPTABLE study will improve care and outcomes for patients with heart disease and could prevent as many as 88,800 deaths per year around the world.

www.theaspirinstudy.org

Rush principal investigator: Raj C. Shah, MD; R. Jeffery Snell, MD

Healthcare Worker Exposure Response & Outcomes (HERO) Registry

Status: Recruitment 

The HERO research program wants to answer crucial questions about the impact of COVID-19 on you, your colleagues, family, and friends. The registry aims to build a community of workers in healthcare who better understand the effects of the pandemic on the front line. Registry members will have the opportunity to participate in research to generate evidence to improve the health and wellbeing of individuals working in the health care setting.

www.heroesresearch.org

National COVID Cohort Collaborative (N3C) Logo

National COVID Cohort Collaborative (N3C)

Status: Data entry

N3C strives to coordinate and harmonize needed data derived from electronic health records to support efforts in understanding how best to direct research efforts and care of COVID-19 patients. 

www.covid.cd2h.org/n3c

CDC Prevention Epicenters Program Logo

Chicago Prevention and Intervention Epicenter (CPIE)

Status: Data entry

CPIE is one of eleven sites of the CDC Prevention Epicenters program. CPIE aims to implement innovative strategies to improve healthcare quality and patient safety through collaborative research. CAPriCORN at Rush is involved in two projects within CPIE; the Epidemoiology of Community- Associated ESBL-Producing Enterobacterales in Cook County and the Common Data Models for Inpatient Antimicrobial Stewardship Programs projects.

www.cdc.gov/hai/epicenters

 

Comparative Incidence and Outcomes of COVID-19 in Solid Organ Transplant Recipients Versus Waitlisted Patients: A Multicenter Study

Status: Data entry

The purpose of this study is to determine the incidence and outcomes of COVID-19 in solid organ transplant recipients and waitlisted patients, in order to provide insight regarding waitlist and transplant management during the COVID-19 pandemic. 

Rush principal investigator: Carlos Santos, MD

Post- Colonoscopy Colorectal Cancer (PCCRC) Cohort Survey

Status: Data entry

The purpose of this study is to examine the incidence of region-wide PCCRC and its correlation to adenoma detection rates and serrated polyp detection rates, especially in patients with Lynch Syndrome. 

Rush prinicipal investigator: Joshua Melson, MD, MPH

Parkinson’s Disease (PD) in Sexual and Gender Minority (SGM) Patients Cohort Study

Status: Data entry

The purpose of this study is to describe the prevalence and clinical characteristics of PD in SGM patients and compare treatment outcomes of SGM and non-SGM patients to examine existing disparities.

Rush principal investigator: Roshni Patel, MD; Natalie Witek, MD, MS

CAPriCORN Anemia Survey

Status: Data entry

The purpose of this study is to understand whether blood transfusions help people with a low blood count have more energy.

Rush principal investigator:  Jisu Kim, MD

CAPriCORN Asthma Survey

Status: Data analysis

The purpose of this study is to determine how people are affected by asthma and other health conditions.

Rush principal investigator:  Christopher Codispoti, MDSindhura Bandi, MD

Characterization of CAPriCORN Sickle Cell Disease Population

Status: Data entry

The purpose of this research study is to understand how sickle cell disease affects the everyday life of individuals with this health condition.

Rush principal investigator:  Lisa Boggio, MD

CAPriCORN Weight Survey

Status: Data analysis

The purpose of this research study is to better understand overweight and obesity. Overweight and obesity are highly prevalent conditions, affecting more than two-thirds of U.S. adults. These conditions are associated an increased risk of illness including conditions such as type 2 diabetes, heart disease, and some cancers.

Rush principal investigator: Steven K. Rothschild, MD; Bradley Appelhans, PhD

Recurrent Clostridium difficile Infection (RCDI) Cohort Survey

Status: Data analysis

The purpose of this study is to better understand how the various symptoms of this condition affect individuals lives.

Rush principal investigator: Michael Lin, MD, MPH

              Bennett, T. D., Moffitt, R. A., Hajagos, J. G., Amor, B., Anand, A., Bissell, M. M., Bradwell, K. R., Bremer, C., Byrd, J. B., Denham, A., DeWitt, P. E., Gabriel, D., Garibaldi, B. T., Girvin, A. T., Guinney, J., Hill, E. L., Hong, S. S., Jimenez, H., Kavuluru, R., … Rutter, J. (2021). Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the US National COVID Cohort Collaborative. JAMA Network, 4(7). https://doi.org/10.1001/jamanetworkopen.2021.16901

             Furmanchuk, A., Liu, M., Song, X., Waitman, L. R., Meurer, J. R., Osinski, K., Stoddard, A., Chrischilles, E., McClay, J. C., Cowell, L. G., Tachinardi, U., Embi, P. J., Mosa, A. S., Mandhadi, V., Shah, R. C., Garcia, D., Angulo, F., Patino, A., Trick, W. E., … Black, B. S. (2021). Effect of the Affordable Care Act on diabetes care at major health centers: newly detected diabetes and diabetes medication management. BMJ Open Diabetes Research & Care, 9(1). https://doi.org/10.1136/bmjdrc-2021-002205

             Jones, W. S., Mulder, H., Wruck, L. M., Pencina, M. J., Kripalani, S., Muñoz, D., Crenshaw, D. L., Effron, M. B., Re, R. N., Gupta, K., Anderson, R. D., Pepine, C. J., Handberg, E. M., Manning, B. R., Jain, S. K., Girotra, S., Riley, D., DeWalt, D. A., Whittle, J., … Benziger, C. P. (2021). Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. The New England Journal of Medicine384(21), 1981–1990. https://doi.org/10.1056/NEJMoa2102137

              Moric, M., Fullam, F., & Buvanendran, A. (2019, October 20). HCAHPS pain scores and effect of repeated blood draws and courtesy: Courtesy and the pain experience [Conference Presentation]. The American Society of Anesthesiology Annual Meeting, Orlando, FL, United States.

             Santos, C., Rhee, Y., Hollinger, E. F., Olaitan, O. K., Schadde, E., Peev, V., Saltzberg, S. N., & Hertl, M. (2021). Comparative incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients versus kidney or kidney-pancreas waitlisted patients: A single-center study. Clinical transplantation, e14362. Advance online publication. https://doi.org/10.1111/ctr.14362

 

 

Contact us

For information on CAPriCORN at Rush, please contact Kyra_R_VanDoren@rush.edu

 

For more information on CAPriCORN at Rush, please contact Kyra VanDoren at Kyra_R_VanDoren@rush.edu.