Doctor Mary Hayden
Mary K. Hayden, MD

Director, Division of Infectious Diseases, Department of Internal Medicine, RUSH Medical College
Director, Division of Clinical Microbiology, RUSH Medical Laboratories
The James R. Lowenstine Professor of Internal Medicine, RUSH Medical College
Professor, Department of Pathology, RUSH Medical College

Mary K. Hayden, MD, is the James Lowenstine Professor of Medicine and a professor of pathology at RUSH Medical College. Her research focuses on the epidemiology and prevention of emerging pathogens, healthcare associated infections, and antibiotic resistance. Recent projects have investigated the genomic epidemiology and control of carbapanemase-producing Enterobacterales and Candida auris in long-term care facilities and across regions, and delineation of factors associated with transmission of SARS-CoV-2 in healthcare settings. She has served on federal public health advisory committees including the CDC Healthcare Infection Control and Prevention Advisory Committee (HICPAC) and the Board of Scientific Counselors for the CDC Office of Infectious Diseases. 


Complete list of publications on MyBibliography

Stefan J. Green, PhD

Co-PI, Regional Innovative Public Health Laboratory
Director, Genomics & Microbiome Core Facility
Director of Core Laboratory Services
Assistant Professor, Department of Internal Medicine

Stefan J. Green, PhD’s research is focused on the interaction of complex microbial communities with hosts across a range of experimental and diseases systems. He has a broad background in microbial ecology and molecular biology, with an emphasis on the acquisition and analysis of next-generation sequence data from biological systems. As Co-Principal Investigator of RIPHL, a public-academic partnership between RUSH University and the Chicago Department of Public Health, his laboratory performs surveillance and outbreak sequencing of SARS-CoV-2 genomes from viral transport medium. Previously, Green was director of the Genome Research Core at the University of Illinois at Chicago (UIC).

Selected publications
  1. Garrett-Bakelman, F.E., Darshi, M., Green, S.J., Gur, R.C., Lin, L., Macias, B.R., McKenna, M.J., Meydan, C., Mishra, T., Nasrini, J. and Piening, B.D., 2019. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364(6436), p.eaau8650.
  2. Keshavarzian, A., Green, S.J., Engen, P.A., Voigt, R.M., Naqib, A., Forsyth, C.B., Mutlu, E. and Shannon, K.M., 2015. Colonic bacterial composition in Parkinson’s disease. Movement Disorders, 30(10), pp.1351-1360.
  3. Naqib, A., Poggi, S. and Green, S.J., 2019. Deconstructing the Polymerase Chain Reaction II: an improved workflow and effects on artifact formation and primer degeneracy. PeerJ, 7, p.e7121.
  4. 4. Ofek-Lalzar, M., Sela, N., Goldman-Voronov, M., Green, S.J., Hadar, Y. and Minz, D., 2014. Niche and host-associated functional signatures of the root surface microbiome. Nature communications, 5(1), pp.1-9.

Complete list of publications on MyBibliography

Hannah Barbian, PhD
Hannah Barbian, PhD

Genomic Epidemiologist, Regional Innovative Public Health Laboratory

Hannah Barbian, PhD’s scientific training and interest are in molecular virology and and pathogen genomics. She received her PhD in molecular biology from the University of Pennsylvania with past research focused on the genomic fate of viruses upon transmission, immune pressure, and chronic infection. Since joining RIPHL as a genomic epidemiologist in October 2021, she performs genomic analyses as part of SARS-CoV-2 and other pathogen genomic surveillance, including outbreak investigation and identifying variants and mutations of interest. Barbian has expertise on the topics of pathogen next-generation sequencing, genotyping, and phylogenetic, mutational, evolutionary, and bioinformatic analyses.

Selected publications
  1. Spencer H, Teran RA, Barbian HJ, Love S, Berg, R, Black SR, Ghinai I, Kerins JL. 2022. Multistate Outbreak of Infection with SARS-CoV-2 Omicron Variant after Event in Chicago, Illinois, USA, 2021. Emerging Infectious Diseases. 2022 Jun.
  2. Barbian HJ, Jackson-Jewett R, Brown CS, Bibollet-Ruche F, Learn GH, Decker T, Kreider EF, Li Y, Denny TN, Sharp PM, Shaw GM, Lifson J, Acosta EP, Saag MS, Bar KJ, Hahn BH. Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee. Retrovirology. 2017 Jun 2;14(1):35.
  3. Barbian HJ, Connell AJ, Avitto AN, Russell RM, Smith AG, Gundlapally MS, Shazad AL, Li Y, Bibollet-Ruche F, Wroblewski EE, Mjungu D, Lonsdorf EV, Stewart FA, Piel AK, Pusey AE, Sharp PM, Hahn BH. CHIIMP: An automated high-throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees. Ecology and Evolution. 2018 Jul 16;8(16):7946-7963.

Complete list of publications on MyBibliography

Sofiya Bobrovska, MPH
Sofiya Bobrovska, MPH

Data Analyst, Regional Innovative Public Health Laboratory 

Sofiya Bobrovska’s areas of interest include infectious diseases and environmental health. She earned an MPH in Epidemiology from University of Illinois Chicago and a BS in Integrative Biology from University of Illinois Urbana-Champaign. Bobrovska joined RIPHL as a data analyst in August 2021. She organizes SARS-CoV-2 specimen intake, guides partnerships, and works with Hannah Barbian and the Chicago Department of Public Health to perform analysis on genomic data.

Select presentations
  1. Bobrovska, S., Fiorillo, M., Ganesh, A., English, K., Green, S., Ghinai, I. Hospitalization risk by SARS-CoV-2 lineages in Chicago, Illinois. Pathogen Genomics Symposium: Genes, Genomes, and Infection. Chicago. 2022 May 4.
  2. Kittner, A., Barbian, H., Bobrovska, S., English, K., Green, S., Hayden, M., & Ghinai, I. Early detection and population surveillance of SARS-CoV-2 variants through variant PCR and genomic sequencing. Pathogen Genomics Symposium: Genes, Genomes, and Infection. Chicago. 2022 May 4.

Kevin J. Kunstman
Kevin J. Kunstman

Laboratory Manager, Genomics & Microbiome Core Facility and Regional Innovative Public Health Laboratory

Kevin Kunstman has 30+ years of experience as a molecular biologist and molecular virologist, with laboratory experience at the BSL3 level. His specialties include Next Generation library prep, sequence data acquisition and analysis, real time PCR, and sequence capture for sequencing. He is responsible for NGS DNA sequencing services, including consultations, study design, DNA library prep, sequencing, and data analyses. Kunstman came to RUSH in January of 2021 to establish the Genomics and Microbiome Core Facility. Previously he was the Assistant Director at the UIC Genome Research Core.

Selected publications
  1. Doyle K, Teran RA, Reefhuis J, Kerins JL, Qiu X, Green SJ, Choi H, Madni SA, Kamal N, Landon E, Albert RC, Pacilli M, Furtado LE, Hayden MK, Kunstman KJ, Bethel C, Megger L, Fricchione MJ, Ghinai I. Multiple Variants of SARS-CoV-2 in a University Outbreak After Spring Break - Chicago, Illinois, March-May 2021. MMWR Morb Mortal Wkly Rep. 2021 Sep 3;70(35):1195-1200. doi: 10.15585/mmwr.mm7035a3. PubMed PMID: 34473687; PubMed Central PMCID: PMC8422867.
  2. Braesel J, Crnkovic CM, Kunstman KJ, Green SJ, Maienschein-Cline M, Orjala J, Murphy BT, Eustáquio AS. Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete. J Nat Prod. 2018 Sep 28;81(9):2057-2068. doi: 10.1021/acs.jnatprod.8b00394. Epub 2018 Aug 15. PubMed PMID: 30110167; PubMed Central PMCID: PMC6174880.
  3. Worobey M, Gemmel M, Teuwen DE, Haselkorn T, Kunstman K, Bunce M, Muyembe JJ, Kabongo JM, Kalengayi RM, Van Marck E, Gilbert MT, Wolinsky SM.Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960. Nature. 2008 Oct 2;455(7213):661-4. doi: 10.1038/nature07390. PubMed PMID: 18833279; PubMed Central PMCID: PMC3682493.
  4. Kunstman KJ, Puffer B, Korber BT, Kuiken C, Smith UR, Kunstman J, Stanton J, Agy M, Shibata R, Yoder AD, Pillai S, Doms RW, Marx P, Wolinsky SM.Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. J Virol. 2003 Nov;77(22):12310-8. doi: 10.1128/jvi.77.22.12310-12318.2003. PubMed PMID: 14581567; PubMed Central PMCID: PMC254294.

Complete list of publications on MyBibliography