The Department of Emergency Medicine is committed to advancing knowledge of best practices and advanced techniques to manage conditions in the emergency department. Researchers in the emergency department have been carrying out highly complex studies and are in the pursuit for new treatments and methods. Learn more about some of our current projects below:
Innovative Support for Patients with SARS-CoV-2 Infections (INSPIRE)
To better understand the initial and prolonged impact of COVID-19, this multi-center study across 8 major institutions seeks to prospectively assess patient-reported outcomes across 6,000 COVID-positive and COVID-negative participants over an 18-month time period. This study led by Dr. Michael Gottlieb and Dr. Robert Weinstein is funded through the Centers for Disease Control and Prevention, and has led to over 20 publications to advance the science of COVID-19.
Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial (ANGLE)
The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade versus use of a standard geometry video laryngoscope blade. Critically ill adults undergoing tracheal intubation in participating EDs and ICUs who meet eligibility criteria will be enrolled and randomly assigned in a 1:1 ratio to either intubation using a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade. The primary outcome is the incidence of successful intubation on the first attempt. The secondary outcome is incidence of hypoxemia during the interval between induction and 2 minutes after tracheal intubation.
Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)
The purpose of this funding opportunity announcement (FOA) is to invite applications for Clinical Centers (Hubs) in Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). SIREN will enable conduct of high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events. SIREN will consist of one Clinical Coordinating Center (CCC), one Data Coordinating Center (DCC) and up to 10 clinical centers (Hubs). A Hub will typically be an academic center or tertiary referral center which will actively enroll patients into every clinical trial performed in SIREN, regardless of disease focus. A Hub will additionally provide scientific leadership and administrative oversight to its multiple satellite sites ("Spokes"). Together the Hub and Spokes will provide access to a large and varying patient population for clinical trials. SIREN will implement a total of at least four large (>1,000 patient) simple, pragmatic clinical trials in the emergency department and pre- hospital settings. The clinical trials will be meritorious, peer–reviewed projects which will be awarded under separate funding announcements.
Contact Us
We welcome all inquiries regarding our research and collaborations to our Vice Chair of Research at Michael_A_Gottlieb@rush.edu.