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Laboratory of Narine Hakobyan, PhD

Our laboratory is focused on basic and translational research of blood-induced joint disease and joint hemostasis in patients with hemophilia. Areas of current interest include the development of diagnostic/prognostic biomarkers and therapeutic targets for hemophilic arthropathy and understanding of the molecular mechanisms underlying the disease process.

Selected publications

Hakobyan N, Valentino LA, Cong L, Enockson C, Song X, Desai S, Radtke R, Fogg LF. Hemarthrosis model in mice: BSS–bleeding severity score assessment system. Haemophilia 2016; in press.

Valentino LA, Cong L, Enockson C, Song X, Scheiflinger F, Muchitsch EM, Turecek PL, Hakobyan N. The Biological Efficacy Profile of BAX 855, a PEGylated Recombinant Factor VIII Molecule. Haemophilia. Haemophilia. 2015; 21(1):58-63.

Valentino LA, Hakobyan N, Enockson C, Simpson ML, Kakodkar NC, Cong L and Song X. Importance of first joint haemorrhage as the trigger of synovitis and arthropathy: Experimental studies. Haemophilia 2012; 18(3):310-8.

Hakobyan N, Enockson C, Cole A, Sumner DR, Valentino LA. Experimental haemophilic arthropathy in a mouse model of a massive hemarthrosis: Gross, radiological, and histological changes. Haemophilia 2008; 14: 804-809. Sun J,

Hakobyan N, Valentino, LA, Feldman BL, Samulski RJ, Monahan PE. Intra-articular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. Blood 2008; 112(12): 4532-41.

Our team


Narine Hakobyan, PhD, assistant professor of pediatric hematology/oncology and biochemistry

Fellows and trainees

Xiangqian Song, PhD


Candace Enockson, MT(ASCP)


For information about current research opportunities, contact Narine Hakobyan, PhD. Our laboratory is located in the Hemophilia and Thrombophilia Center, Jelke Building, Room 1599, 1750 W. Harrison St., Chicago, IL 60612.