Laboratory of Frank Ko, PhD

The research of Frank Ko, PhD, explores mechanisms underlying musculoskeletal homeostasis, diseases, and repair.  Understanding these mechanisms could lead to a development of novel therapeutic interventions to diseases such as osteoporosis, osteoarthritis, or sarcopenia.

Our work

Ko’s lab at Rush has been studying how extrinsic (eg. diet, physical activity, injury) or intrinsic (eg. genetics) factors and their underlying mechanisms leading to alterations in the musculoskeletal tissue.  The recent effort focuses on examining the role of periostin expressing cells in intramembranous bone regeneration.  These cells, while normally restricted to the periosteal surface and absent in bone marrow, are present in the regenerating marrow cavity following marrow ablation surgery.  Understanding the periostin expressing cell lineage commitment and the underlying mechanisms during intramembranous bone regeneration could pave a way to enhance fracture healing or improve implant fixation.

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  • NIH K01AR077679 (role: PI): “Role of periostin expressing cells in intramembranous bone regeneration.”
  • ORS Collaborative Exchange Grant (role: PI): Scientific collaboration to implement light and expansion microscopy for musculoskeletal tissues.

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A full list of Frank Ko’s research publications can be found on PubMed.

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Frank Ko, PhD
Assistant Professor
Department of Anatomy & Cell Biology
Rush University Medical Center
Armour Academic Facility
600 S Paulina St. Room 506B
Chicago, IL 60612
Phone: (312) 942-8294

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