Neurosurgery Research

The Department of Neurological Surgery is deeply committed to advancing knowledge and the pursuit of progress in new techniques and treatments in neurosurgery. As both clinicians and researchers in a dynamic academic medical center, neurosurgeons at Rush consistently translate significant scientific innovations into health gains for patients. Continuous investment in basic biomedical and behavioral discovery in concert with translational science ensures that both of these disciplines remain powerful engines of creativity.

Our research efforts have been focused in the following three broad areas:

Brain tumor and functional neurosurgery

INTREPID Trial
Implantable neurostimulator for the treatment of Parkinson’s disease (INTREPID trial).

Treatment of Parkinson’s Patients Using Levodopa Study
Safety and efficacy study of SYN115 in Parkinson’s patients using levodopa to treat end of dose wearing off (TOZPD).

Spine

Cervical Spinal Cord Injury Treatment Study
A phase 1/2a dose escalation study of AST-OPC1 in subjects with subacute cervical spinal cord injury.

Infection Prevention During Spine Surgery Study
Safety and efficacy of Staphylococcus aureus vaccine in adults undergoing elective posterior instrumented lumbar spinal fusion procedures.

Endovascular Neurosurgery

DAWN Trial
DAWN: Prospective, randomized, blinded endpoint, control trial evaluating the Trevo Retrievers in the 6-24 hour after LKW period.

FRED Study
FRED: Pivotal study of the MicroVention Flow Re-Direction Endoluminal Device stent system in the treatment of intracranial aneurysms

Neurovascular Self-Expanding Retrievable Stent System Study
Pivotal study of the Microvention Inc. neurovascular self-expanding retrievable stent system LVIS

SCENT Trial
SCENT trial: Surpass intracranial aneurysm embolization system pivotal study to treat large or giant wide neck aneurysms

WEAVE Trial
WEAVE trial: Wingspan stent system post-market surveillance study