The research of Kathrin Banach, PhD, focuses on the cellular mechanism of atrial fibrillation, or AF, which is the most common cardiac arrhythmia in clinical practice that can precipitate heart failure, stroke and even death.
Antonio Bianco, MD, PhD is interested in understanding the aspects of thyroid hormone action that involve the iodothyronine deiodinases D1, D2 and D3. The Bianco lab investigates the physiological roles played by these enzymes and their involvement in disease mechanisms. Knowledge obtained from these studies will help develop therapeutic approaches that regulate thyroid hormone action and preserve thyroid hormone homeostasis in patients with hypothyroidism.
The research group of Lothar Blatter, MD, Dr Med, investigates control of intracellular calcium and its role in the regulation of excitation-contraction and excitation-transcription coupling in cells of the cardiovascular system.
The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor, or RyR, Ca release channel in excitable cells.
The lab of Dirk Gillespie, PhD, has three main focuses, both studied by modeling and simulations: calcium-induced calcium release, or CICR, in cardiac skeletal muscle, Ca2+ movement during heart muscle contraction and nanofluidics and its applications.
Vineet Gupta, PhD, studies cell adhesion receptors, called integrins, and how they regulate a variety of biological processes.
The research in the laboratory of Sanda Predescu, PhD, is focused on the molecular mechanisms of endothelial cell functions in normal and pathological conditions and how intersectin proteins regulate these functions.
The research of Josefina Ramos-Franco, MD, PhD, is focused on the control mechanisms of intracellular Ca2+ release in excitable cells.
The research of Thomas Shannon, PhD, explores the local control of excitation-contraction coupling in excitable cells.