Laboratory of Ryan Ross, PhD

The research of Ryan Ross, PhD, is in the field of skeletal biology. We are particularly interested in the role of mineralization and other bone quality factors that influence skeletal function.

Our work

Mineralization is the final step in the bone formation phase, providing the skeleton with its characteristic strength. Additionally, the mineral within the bone provides an important ion reserve to maintain the necessary calcium and phosphate for numerous biological processes. Our lab is interested in understanding the process of mineralization with the aim of improving treatments for skeletal diseases such as osteoporosis. We are also working to test novel treatment strategies for diseases of aberrant mineralization (osteomalacia).

Mineralization is controlled at the local, bone level, as well as systemically, where several organ systems influence the availability of calcium and phosphate. Recently, it has become apparent that the skeleton is not a silent player in this process and instead produces proteins with hormonal function. As our research has branched into the systemic control of mineralization, we have also become interested in the interaction between the skeleton and non-bone organs and the contributions of these interactions to health and disease.

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Technology and methods

We use a variety of methods to investigate bone quality and mineralization:

  • Micro-computed tomography
  • Mechanical testing
  • Backscattered scanning electron microscopy
  • Fourier transform infrared spectroscopy
  • Dynamic and static histomorphometry
  • Immunochemical staining
  • Cell culture of mineralizing osteoblasts
  • Animal models: surgical, non-surgical and transgenic
  • PCR, ELISA, Luminex

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Publications

A full list of Ryan Ross’ research publications can be found on PubMed.

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Contact

Ryan Ross, PhD
Assistant Professor
Department of Cell & Molecular Medicine
Rush University Medical Center
Armour Academic Facility
600 S Paulina St. Room 512B
Chicago, IL 60612
Phone: (312) 942-5959
Email: ryan_ross@rush.edu

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