Laboratory of Ryan Ross, PhD

The research of Ryan Ross, PhD, is in the field of skeletal biology. We are particularly interested in the role of mineralization and other bone quality factors that influence skeletal function.

Our work

Mineralization is the final step in the bone formation phase, providing the skeleton with its characteristic strength. Additionally, the mineral within the bone provides an important ion reserve to maintain the necessary calcium and phosphate for numerous biological processes. Our lab is interested in understanding the process of mineralization with the aim of improving treatments for skeletal diseases such as osteoporosis. We are also working to test novel treatment strategies for diseases of aberrant mineralization (osteomalacia).

Mineralization is controlled at the local, bone level, as well as systemically, where several organ systems influence the availability of calcium and phosphate. Recently, it has become apparent that the skeleton is not a silent player in this process and instead produces proteins with hormonal function. As our research has branched into the systemic control of mineralization, we have also become interested in the interaction between the skeleton and non-bone organs and the contributions of these interactions to health and disease.

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Technology and methods

We use a variety of methods to investigate bone quality and mineralization:

  • Micro-computed tomography
  • Mechanical testing
  • Backscattered scanning electron microscopy
  • Fourier transform infrared spectroscopy
  • Dynamic and static histomorphometry
  • Immunochemical staining
  • Cell culture of mineralizing osteoblasts
  • Animal models: surgical, non-surgical and transgenic
  • PCR, ELISA, Luminex

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Publications

A full list of Ryan Ross’ research publications can be found on PubMed.

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Our team

Kelsey Carpenter

I grew up in southeast Michigan and earned a Bachelor of Science in anthropology at Michigan State University. I then attended Mercyhurst University where I completed a Master of Science in biological and forensic anthropology. My graduate education in the Integrated Biomedical Sciences PhD program at Rush University began in the fall of 2017.
My dissertation research is focused on X-linked hypophosphatemia (XLH), a rare metabolic bone disease. XLH is the most common form of heritable rickets and is first diagnosed in children who present with shortened stature, leg bowing, low bone mass, and increased fracture risk. My project involves using a mouse model of XLH to investigate different treatment options for the disease. Methods used to complete this study include micro-computed tomography, ELISA, quantitative PCR, and histology. The goal of this study is to improve phosphate metabolism and skeletal mineralization, ultimately leading to improved stature, bone mass and overall quality of life for patients with XLH.

Kyle Anderson

I am particularly interested in understanding changes in bone biology in specific disease states and unique physiological environments. My work examines a wide variety of topics regarding bone alterations in: Human Immunodeficiency Virus (HIV), X-linked Hypophosphatemia (XLH), hindlimb suspension, and spaceflight related osteopenia. The studies utilize back Scatter Electron Microscopy (bSEM) and microcomputed tomography (µCT) to evaluate changes in bone quality.
The primary objective of my work is to better understand bone mineralization in these specific physiological states and how medications such as bisphosphonates as well as sclerostin-antibody (romosozumab) can better manage them.
While I was born in Chicago, I grew up in southeast Michigan and attended Michigan State University and studied human biology and philosophy. I then attended the University of Michigan for a master’s in physiology with a research focus on adrenal endocrinology. I am now happily back in Chicago as of the fall of 2016 where I began medical school at Rush Medical College.

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Contact

Ryan Ross, PhD
Assistant Professor
Department of Cell & Molecular Medicine
Rush University Medical Center
Armour Academic Facility
600 S Paulina St. Room 512B
Chicago, IL 60612
Phone: (312) 942-5959
Email: ryan_ross@rush.edu

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