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Recent Publications

Wuthrich C, Batson S, Koralnik IJ. Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System. J Neuropathol Exp Neurol. 2015 Aug; 74(8):791-803. Read article

Miskin DP, Koralnik IJ. Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area. Curr Opin Neurol. 2015 Jun; 28(3):288-94. Read article

Agnihotri SP, Koralnik IJ. Training for a neurology career in a rare disease: The role of cyberconsults. Ann Neurol. 2015 May; 77(5):738-40. Read article

Siddiqi OK, Elafros MA, Sikazwe I, Birbeck GL, Kalungwana L, Potchen MJ, Bositis CM, Koralnik IJ, Theodore WH. Acute EEG findings in HIV-infected Zambian adults with new-onset seizure. Neurology. 2015 Mar 31; 84(13):1317-22. Read article

Koralnik IJ. Finger pointing to JC virus: A tale of two indexes. Ann Neurol. 2014 Dec; 76(6):789-91. Read article

Kalungwana L, Elafros MA, Siddiqi OK, Bositis CM, Sikazwe I, Koralnik IJ, Theodore WH, Birbeck GL. Cognitive Impairment and Psychiatric Morbidity in HIV+ Zambians with New-Onset Seizure. Am J Trop Med Hyg. 2014 Dec 3; 91(6):1254-8. Read article

Agnihotri SP, Dang X, Carter JL, Fife TD, Bord E, Batson S, Koralnik IJ. JCV GCN in a natalizumab-treated MS patient is associated with mutations of the VP1 capsid gene. Neurology. 2014 Aug 19; 83(8):727-32. Read article

Agnihotri SP, Wuthrich C, Dang X, Nauen D, Karimi R, Viscidi R, Bord E, Batson S, Troncoso J, Koralnik IJ. A fatal case of JC virus meningitis presenting with hydrocephalus in a human immunodeficiency virus-seronegative patient. Ann Neurol. 2014 Jul; 76(1):140-7. Read article

Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34. Read article

Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014 May; 75(5):659-69. Read article

Dang L, Dang X, Koralnik IJ, Todd PK. JC Polyomavirus Granule Cell Neuronopathy in a Patient Treated With Rituximab. JAMA Neurol. 2014 Apr 1; 71(4):487-9. Read article

Schwenk H, Ramirez-Avila L, Sheu SH, Wuthrich C, Waugh J, Was A, Degirolami U, Burchett S, Koralnik IJ, Ahmed A. Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review. Pediatr Infect Dis J. 2014 Apr; 33(4):e99-e105. Read article

Tan CS, Broge TA, Ngo L, Gheuens S, Viscidi R, Bord E, Rosenblatt J, Wong M, Avigan D, Koralnik IJ. Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Selective Control of JC Virus Reactivation. Biol Blood Marrow Transplant. 2014 Jul; 20(7):992-9. Read article

Siddiqi OK, Ghebremichael M, Dang X, Atadzhanov M, Kaonga P, Khoury MN, Koralnik IJ. Molecular Diagnosis of Central Nervous System Opportunistic Infections in HIV-Infected Zambian Adults. Clin Infect Dis. 2014 Jun 15; 58(12):1771-7. Read article

Ellis LC, Norton E, Dang X, Koralnik IJ. Agnogene Deletion in a Novel Pathogenic JC Virus Isolate Impairs VP1 Expression and Virion Production. PLoS One. 2013; 8(11):e80840. Read article

Wüthrich C, Popescu BF, Gheuens S, Marvi M, Ziman R, Denq SP, Tham M, Norton E, Parisi JE, Dang X, Lucchinetti CF, Koralnik IJ. Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. J Neuropathol Exp Neurol. 2013 Nov; 72(11):1043-51. Read article

Khoury MN, Gheuens S, Ngo L, Wang X, Alsop DC, Koralnik IJ. Hyperperfusion in progressive multifocal leukoencephalopathy is associated with disease progression and absence of immune reconstitution inflammatory syndrome. Brain. 2013 Nov; 136(Pt 11):3441-50. Read article

Kaliyaperumal S, Dang X, Wuethrich C, Knight HL, Pearson C, Mackey J, Mansfield KG, Koralnik IJ, Westmoreland SV. Frequent Infection of Neurons by SV40 Virus in SIV-Infected Macaque Monkeys with Progressive Multifocal Leukoencephalopathy and Meningoencephalitis. Am J Pathol. 2013 Dec; 183(6):1910-7. Read article

Dang X, Koralnik IJ. Gone over to the dark side: Natalizumab-associated JC virus infection of neurons in cerebellar gray matter. Ann Neurol. 2013 Oct; 74(4):503-5. Read article

Khoury MN, Mittleman MA, Koralnik IJ. ABO Blood Groups and Risk for Progressive Multifocal Leukoencephalopathy. JAMA Neurol. 2013 Oct; 70(10):1331-2. Read article

Khoury MN, Tan CS, Peaslee M, Koralnik IJ. CSF viral escape in a patient with HIV-associated neurocognitive disorder. J Neurovirol. 2013 Aug; 19(4):402-5. Read article

Tan CS, Broge TA, Seung E, Vrbanac V, Viscidi R, Gordon J, Tager AM, Koralnik IJ. Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model. PLoS One. 2013; 8(5):e64313. Read article

Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology. 2013 Apr 9; 80(15):1430-8. Read article

Siddiqi OK, Koralnik IJ, Atadzhanov M, Birbeck GL. Emerging Subspecialties in Neurology: Global health. Neurology. 2013 Feb 19; 80(8):e78-80. Read article

Koralnik IJ, Clifford DB. Comment: Avoiding detrimental effects of corticosteroids on JC virus T-cell responses--Primum non nocere. Neurology. 2012 Dec 4; 79(23):2263. Read article

Marousi S, Travasarou M, Karageorgiou CE, Gheuens S, Koralnik IJ. Simultaneous Pml-Iris After Discontinuation of Natalizumab in A Patient With MS. Neurology. 2012 Nov 20; 79(21):2160. Read article

Gheuens S, Wuthrich C, Koralnik IJ. Progressive multifocal leukoencephalopathy: why gray and white matter. Annu Rev Pathol. 2013 Jan 24; 8:189-215. Read article

Gheuens S, Ngo L, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Metabolic profile of PML lesions in patients with and without IRIS: an observational study. Neurology. 2012 Sep 4; 79(10):1041-8.  Read article

Tan CS, Bord E, Broge TA, Glotzbecker B, Mills H, Gheuens S, Rosenblatt J, Avigan D, Koralnik IJ. Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy. J Acquir Immune Defic Syndr. 2012 Jul 1; 60(3):244-8. Read article

Dang X, Wuthrich C, Gordon J, Sawa H, Koralnik IJ. JC virus encephalopathy is associated with a novel agnoprotein-deletion JCV variant. PLoS One. 2012; 7(4):e35793. Read article

Gheuens S, Smith DR, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 2012 May 1;78(18):1390-3. Read article

Sethi NK, Torgovnick J, McArthur JC, Tan IL, Koralnik IJ. Progressive Multifocal Leukoencephalopathy in a Patient without Immunodeficiency. Neurology. 2012 Jan 3; 78(1):73-4. Read article

Wuthrich C, Koralnik IJ. Frequent Infection of Cortical Neurons by JC Virus in Patients With Progressive Multifocal Leukoencephalopathy. J Neuropathol Exp Neurol. 2012 Jan; 71(1):54-65. Read article

Dang X, Vidal JE, Penalva de Oliveira AC, Simpson DM, Morgello S, Hecht JH, Ngo LH, Koralnik IJ. JC virus granule cell neuronopathy is associated with VP1 C terminus mutants. J Gen Virol. 2012 Jan; 93(Pt 1):175-83. Read article

Gheuens S, Cheeseman SH, Koralnik IJ. Hidden in plain view: emergence of progressive multifocal leukoencephalopathy after treatment of CNS toxoplasmosis. Acta Neurol Belg. 2011 Sep; 111(3):217-9. Read article

Viscidi RP, Khanna N, Tan CS, Li X, Jacobson L, Clifford DB, Nath A, Margolick JB, Shah KV, Hirsch HH, Koralnik IJ. JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals. Clin Infect Dis. 2011 Oct; 53(7):711-5. Read article

McGuire JL, Fridman V, Wuthrich C, Koralnik IJ, Jacobs D. Progressive multifocal leukoencephalopathy associated with isolated CD8+ T-lymphocyte deficiency mimicking tumefactive MS. J Neurovirol. 2011 Oct; 17(5):500-3. Read article

Aquino K, Koralnik IJ, Silvers D. Clinical Reasoning: An 83-year-old woman with progressive hemiataxia, tremor, and infratentorial lesions. Neurology. 2011 Jul 12; 77(2):e7-10. Read article

Tan IL, Koralnik IJ, Rumbaugh JA, Burger PC, King-Rennie A, McArthur JC. Progressive multifocal leukoencephalopathy in a patient without immunodeficiency. Neurology. 2011 Jul 19; 77(3):297-9. Read article

Gheuens S, Bord E, Kesari S, Simpson DM, Gandhi RT, Clifford DB, Berger JR, Ngo L, Koralnik IJ. Role of CD4+ and CD8+ T-cell responses against JC virus in the outcome of patients with progressive multifocal leukoencephalopathy (PML) and PML with immune reconstitution inflammatory syndrome. J Virol. 2011 Jul; 85(14):7256-63. Read article

Dang X, Bialasiewicz S, Nissen MD, Sloots TP, Koralnik IJ, Tan CS. Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. PLoS One. 2011; 6(3):e16736. Read article

Lima MA, Bernal-Cano F, Clifford DB, Gandhi RT, Koralnik IJ. Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy. J Neurol Neurosurg Psychiatry. 2010 Nov; 81(11):1288-91. Read article

Tan CS, Ellis LC, Wuthrich C, Ngo L, Broge TA, Saint-Aubyn J, Miller JS, Koralnik IJ. JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol. 2010 Sep; 84(18):9200-9. Read article

Tan CS, Chen Y, Viscidi RP, Kinkel RP, Stein MC, Koralnik IJ. Discrepant findings in immune responses to JC virus in patients receiving natalizumab. Lancet Neurol. 2010 Jun; 9(6):565-6; author reply 566-7. Read article

Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010 Apr; 9(4):425-37. Read article

Gheuens S, Fellay J, Goldstein DB, Koralnik IJ. Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy. J Neurovirol. 2010 Feb; 16(1):41-7. Read article

Siddiqi OK, Atadzhanov M, Birbeck GL, Koralnik IJ. The spectrum of neurological disorders in a Zambian tertiary care hospital. J Neurol Sci. 2010 Mar 15; 290(1-2):1-5. Read article

Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ. Determinants of survival in progressive multifocal leukoencephalopathy. Neurology. 2009 Nov 10; 73(19):1551-8. Read article

Gheuens S, Pierone G, Peeters P, Koralnik IJ. Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry. 2010 Mar; 81(3):247-54. Read article

Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW. Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis. 2009 Oct; 9(10):625-36. Read article

Chen Y, Bord E, Tompkins T, Miller J, Tan CS, Kinkel RP, Stein MC, Viscidi RP, Ngo LH, Koralnik IJ. Asymptomatic reactivation of JC virus in patients treated with natalizumab. N Engl J Med. 2009 Sep 10; 361(11):1067-74. Read article

Wuthrich C, Dang X, Westmoreland S, McKay J, Maheshwari A, Anderson MP, Ropper AH, Viscidi RP, Koralnik IJ. Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons. Ann Neurol. 2009 Jun; 65(6):742-8. Read article

Tan CS, Dezube BJ, Bhargava P, Autissier P, Wuthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation. J Infect Dis. 2009 Mar 15; 199(6):881-8. Read article

Wuthrich C, Cheng YM, Joseph JT, Kesari S, Beckwith C, Stopa E, Bell JE, Koralnik IJ. Frequent infection of cerebellar granule cell neurons by polyomavirus JC in progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol. 2009 Jan; 68(1):15-25. Read article

Marzocchetti A, Lima M, Tompkins T, Kavanagh DG, Gandhi RT, O'Neill DW, Bhardwaj N, Koralnik IJ. Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy. Virology. 2009 Jan 20; 383(2):173-7. Read article

Marzocchetti A, Wuthrich C, Tan CS, Tompkins T, Bernal-Cano F, Bhargava P, Ropper AH, Koralnik IJ. Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy. J Neurovirol. 2008 Oct; 14(5):455-8. Read article

Dang X, Wuthrich C, Axthelm MK, Koralnik IJ. Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeys. J Neuropathol Exp Neurol. 2008 Aug; 67(8):784-92. Read article

Kesari S, Akar S, Saad A, Drappatz J, Koralnik IJ, DeAngelo DJ. Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia. J Clin Oncol. 2008 Aug 1; 26(22):3804-7. Read article

Chen Y, Trofe J, Gordon J, Autissier P, Woodle ES, Koralnik IJ. BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy. J Clin Virol. 2008 Jun; 42(2):198-202. Read article

Bernal-Cano F, Joseph JT, Koralnik IJ. Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired immunodeficiency syndrome patient. J Neurovirol. 2007 Oct; 13(5):474-6. Read article

Yang W, Beaudoin EL, Lu L, Du Pasquier RA, Kuroda MJ, Willemsen RA, Koralnik IJ, Junghans RP. Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int Immunol. 2007 Sep; 19(9):1083-93. Read article

Verma S, Cikurel K, Koralnik IJ, Morgello S, Cunningham-Rundles C, Weinstein ZR, Bergmann C, Simpson DM. Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera. J Infect Dis. 2007 Sep 1; 196(5):709-11. Read article

Lima MA, Katz-Brull R, Lenkinski RE, Nunez R, Feinrider D, Koralnik IJ. Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient. Eur J Neurol. 2007 Jun; 14(6):598-602. Read article

Lima MA, Marzocchetti A, Autissier P, Tompkins T, Chen Y, Gordon J, Clifford DB, Gandhi RT, Venna N, Berger JR, Koralnik IJ. Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. J Virol. 2007 Apr; 81(7):3361-8. Read article

Dang X, Koralnik IJ. A granule cell neuron-associated JC virus variant has a unique deletion in the VP1 gene. J Gen Virol. 2006 Sep; 87(Pt 9):2533-7. Read article

Vulliemoz S, Lurati-Ruiz F, Borruat FX, Delavelle J, Koralnik IJ, Kuntzer T, Bogousslavsky J, Picard F, Landis T, Du Pasquier RA. Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis. J Neurol Neurosurg Psychiatry. 2006 Sep; 77(9):1079-82. Read article

Koralnik IJ. Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name? Ann Neurol. 2006 Aug; 60(2):162-73. Read article

Du Pasquier RA, Stein MC, Lima MA, Dang X, Jean-Jacques J, Zheng Y, Letvin NL, Koralnik IJ. JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients. J Neuroimmunol. 2006 Jul; 176(1-2):181-6. Read article

Wuthrich C, Kesari S, Kim WK, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol. 2006 Apr; 12(2):116-28. Read article

Chen Y, Trofe J, Gordon J, Du Pasquier RA, Roy-Chaudhury P, Kuroda MJ, Woodle ES, Khalili K, Koralnik IJ. Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy. J Virol. 2006 Apr; 80(7):3495-505. Read article

Lima MA, Drislane FW, Koralnik IJ. Seizures and their outcome in progressive multifocal leukoencephalopathy. Neurology. 2006 Jan 24; 66(2):262-4. Read article