Research of Elizabeth McAninch, MD


Elizabeth McAninch, MD, is an Assistant Professor in the Division of Endocrinology and Metabolism at Rush University Medical Center in Chicago, Illinois. Her research focuses on understanding aspects of thyroid hormone metabolism and genetic differences that impact these pathways. Translational application of these studies will help develop strategies that preserve thyroid hormone homeostasis in patients with hypothyroidism.


Bianco, A.C., McAninch, E.A. The role of thyroid hormone and brown adipose tissue in energy homoeostasis (2013) The Lancet Diabetes and Endocrinology, 1 (3), pp. 250-258.

Mcaninch, E.A., Bianco, A.C. Thyroid hormone signaling in energy homeostasis and energy metabolism (2014) Annals of the New York Academy of Sciences, 1311 (1), pp. 77-87.

Fonseca, T.L., Werneck-De-Castro, J.P., Castillo, M., Bocco, B.M.L.C., Fernandes, G.W., McAninch, E.A., Ignacio, D.L., Moises, C.C.S., Ferreira, A., Gereben, B., Bianco, A.C. Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse (2014) Diabetes, 63 (5), pp. 1594-1604.

McAninch, E.A., Bianco, A.C. The Thr92AlaD2 polymorphism may play a novel role in hypothyroidism (2015) US Endocrinology, 11 (2), pp. 92-94.

McAninch, E.A., Miller, B.T., Ueta, C.B., Jo, S., Kim, B.W. Thyroid hormone at near physiologic concentrations acutely increases oxygen consumption and extracellular acidification in LH86 hepatoma cells (2015) Endocrinology, 156 (11), pp. 4325-4335.

McAninch, E.A., Jo, S., Preite, N.Z., Farkas, E., Mohácsik, P., Fekete, C., Egri, P., Gereben, B., Li, Y., Deng, Y., Patti, M.-E., Zevenbergen, C., Peeters, R.P., Mash, D.C., Bianco, A.C. Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes (2015) Journal of Clinical Endocrinology and Metabolism, 100 (3), pp. 920-933.

De Castro, J.P.W., Fonseca, T.L., Ueta, C.B., McAninch, E.A., Abdalla, S., Wittmann, G., Lechan, R.M., Gereben, B., Bianco, A.C. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine (2015) Journal of Clinical Investigation, 125 (2), pp. 769-781.

McAninch, E.A., Fonseca, T.L., Poggioli, R., Panos, A.L., Salerno, T.A., Deng, Y., Li, Y., Bianco, A.C., Iacobellis, G. Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease (2015) Obesity, 23 (6), pp. 1267-1278.

McAninch, E.A., Bianco, A.C. New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism (2015) The Lancet Diabetes and Endocrinology, 3 (10), pp. 756-758.

Gereben, B., McAninch, E.A., Ribeiro, M.O., Bianco, A.C. Scope and limitations of iodothyronine deiodinases in hypothyroidism (2015) Nature Reviews Endocrinology, 11 (11), pp. 642-652.

Fonseca, T.L., Fernandes, G.W., McAninch, E.A., Bocco, B.M.L.C., Abdalla, S.M., Ribeiro, M.O., Mohácsik, P., Fekete, C., Li, D., Xing, X., Wang, T., Gereben, B., Bianco, A.C. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity (2015) Proceedings of the National Academy of Sciences of the United States of America, 112 (45), pp. 14018-14023.

McAninch, E.A., Bianco, A.C. The history and future of treatment of hypothyroidism (2016) Annals of Internal Medicine, 164 (1), pp. 50-56.

Kim, B.W., Yousman, W., Wong, W.X., Cheng, C., McAninch, E.A. Less is more: Comparing the 2015 and 2009 American thyroid association guidelines for thyroid nodules and cancer (2016) Thyroid, 26 (6), pp. 759-764.

Bocco, B.M.L.C., Werneck-De-castro, J.P., Oliveira, K.C., Fernandes, G.W., Fonseca, T.L., Nascimento, B.P.P., Mcaninch, E.A., Ricci, E., Kvárta-Papp, Z., Fekete, C., Bernardi, M.M., Gereben, B., Bianco, A.C., Ribeiro, M.O. Type 2 deiodinase disruption in astrocytes results in anxiety-depressive-like behavior in male mice (2016) Endocrinology, 157 (9), pp. 3682-3695.

Rajan, K.B., Arvanitakis, Z., Lynch, E.B., McAninch, E.A., Wilson, R.S., Weuve, J., Barnes, L.L., Bianco, A.C., Evans, D.A. Cognitive decline following incident and preexisting diabetes mellitus in a population sample (2016) Neurology, 87 (16), pp. 1681-1687.

Peterson, S.J., McAninch, E.A., Bianco, A.C. Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? (2016) Journal of Clinical Endocrinology and Metabolism, 101 (12), pp. 4964-4973.

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