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African-American, White, Latino Children Have Different Food Allergen Profiles

African-American, White, Latino Children Have Different Food Allergen Profiles

(CHICAGO) – Researchers have found that both African-American and Latino children have significantly higher rates of corn, shellfish and fish allergies than white children, confirming that race and ethnicity play an important role in how people are affected by food allergy.

The findings come from the first study designed to assess and characterize the racial and ethnic difference in food allergies among children in the United States. The study was conducted by allergy and immunology experts at Rush University Medical Center, Cincinnati Children’s Hospital Medical Center and Ann & Robert H. Lurie Children’s Hospital of Chicago. 

Results of the study were published in the Nov. 21 issue of the Journal of Allergy and Clinical Immunology: In Practice.

“Food allergy is a prevalent condition in the U.S., but little is known about its characteristics and severity in racial minority groups,” said Dr. Mahboobeh Mahdavinia, the study’s principal investigator and lead author, and an allergy and immunology expert at Rush. “Our goal was to characterize the food allergy related outcomes in these children and to identify any disparities in health care usage among African-American, Latino and white children with food allergy.”

Study included 817 children seen at hospitals for food allergies

Food allergy is an immune system reaction that occurs soon after eating a certain food. Even a tiny amount of the food individuals are allergic to can trigger signs and symptoms, such as digestive problems, hives, breathing problems or anaphylaxis (a severe, potentially fatal allergic reaction). Food allergy is major public health concern, affecting eight percent of children in the U.S. with an estimated economic burden of $24.8 billion annually.

“It has been well documented that the prevalence of food allergy has been increasing in children in the U.S., but little data and research exists about its frequency, severity and outcomes among minority race and ethnicities in the U.S.,” said Mahdavinia.

Mahdavinia and her colleagues at Rush, Cincinnati Children’s Hospital Medical Center and Lurie Children’s conducted a large study of children ranging in age from birth to 17 who were diagnosed with food allergy and were seen in allergy/immunology clinics at two urban tertiary care centers in the U.S.  

The study included 817 children in all and was composed of 35 percent African-Americans, 12 percent Latino, and 53 percent non-Hispanic white children.

African-American, Latino children received less care for food allergies

Results of the study indicate that compared with non-Hispanic, white children, African-American children had significantly higher odds of having asthma and eczema, as well as significantly higher odds of allergy to wheat, soy, corn, fish and shellfish.

“We found African-American children had a significantly higher rate of wheat allergy than did white children,” Mahdavinia said. “The higher rate of wheat allergy among African American children could potentially explain the higher rates of anaphylaxis, which is a severe allergic reaction that requires immediate care, and the emergency room visits observed in this population.”

“Wheat-based bread is a staple in the U.S. and consumed on a daily basis in most U.S. households, with an average consumption of more than 130 pounds per person per year. Wheat allergy can be a significant financial burden, especially for low-income families,” Mahdavinia added. 

Latino children had significantly higher odds of allergy to corn, fish and shellfish, but a similar rate of asthma compared to non-Hispanic white children. The rate of corn allergy in Latinos could be due to corn being a major food staple in Mexican and other Latino families.

The study also found that compared with whites, African American and Latino children received less follow-up care for food allergy from an allergy specialist and had higher rates of food allergy related anaphylaxis and emergency room visits.

African-American and Latino children have higher odds of ER visits

In this study, 55 percent of African-American, 18 percent of Latino and 11 percent of white children were covered by Medicaid, indicating lower income rates among the African American families participating in the study. 

Low-income children incur higher costs for emergency room visits and hospitalization and spend less on specialty care. Shorter follow-up duration can negatively affect food allergy outcomes and can increase rate of death.

Peanut was the most common food allergen in all three groups. The only allergen more common among white children than African American and Latino children was tree nut. Tree nut allergies are distinct from peanut allergy because peanuts are legumes, whereas a tree nut is a hard-shelled fruit.

“A major concern is that African-American and Hispanic children had significantly higher rates of food-induced anaphylaxis than white children. Furthermore, African-American and Hispanic children also had higher odds of emergency room visits for food allergy related reactions compared to white children,” said Mahdavinia.

Doctors should be on lookout for racially prevalent allergies

“The three centers evaluated their patient population separately, but when we pooled the data together we saw the striking similarity of the findings among the centers, which confirmed our initial suspicion that food allergies present differently in various races. This is an important issue to make pediatricians and allergist aware of so they can look for the relevant allergies in each of the various races,” said Dr. Amal Assa’ad, study co-author and allergy and immunology expert at Cincinnati Children’s Hospital Medical Center.

“We found a difference in the insurance coverage among the various races, which may impact access to care and adherence to follow up visits and avoidance measures,” added Assa’ad.

“We need to conduct further research to identify food allergy and food sensitivities among all races and ethnicities so we can develop culturally-sensitive and effective educational programs to improve food allergy outcomes for all children,” Mahdavinia said.

“It is critically important for us to understand food allergy in children of different races and ethnicities, so we can improve management for all children,” said Dr. Ruchi Gupta, senior author of the study, pediatrician and researcher at Ann & Robert H. Lurie Children’s Hospital of Chicago and associate professor of pediatrics and medicine at Northwestern University Feinberg School of Medicine.

Co-authors from Rush, Cincinnati Children’s, and Lurie Children’s include Dr. Amal Assad, Dr. Erica Palmisano, Dr. Aisha Mohamed, Dr. Christine James, Bridget Smith, PhD, Dr. Zeeshan Zahid, Dr. Mary Kay Tobin and physician assistant Susan Fox.

Media contact:
Deb Song
(312) 942-0588