Xian-Ming Chen, MD

Biography

Xian-Ming Chen, MD, is a faculty member in the Department of Microbial Pathogens and Immunity. He received graduate training in China and conducted a Sasakawa Scholarship fellowship in Japan and a second research fellowship at Mayo Clinic. His research interests focus on the regulatory role for ncRNAs in mucosal innate defense and in host-pathogen interactions. Specifically, his research group studies the expression of ncRNA genes and their role in regulation of immune responses of innate immune cells and epithelial cells in the gastrointestinal tract; interactions between gastrointestinal epithelial cells and Cryptosporidium (a long-recognized cause of chronic and life-threatening enteric disease in HIV-AIDS patients and one of the most common pathogens responsible for moderate-to-severe diarrhea in young children worldwide); and the ncRNA signatures that may link mucosal inflammation to the tumorigenesis and other infectious diseases. He served on several NIH study sections and international grant review panels.

Honors and Activities

Sasakawa Scholar Award, Japan-China Medical Association (1993)
State Distinguished Young Investigator Award (1994)
Internal Medicine Research Award, Mayo Clinic College of Medicine (1998)
Creighton University School of Medicine, New Initiative Award (2010)
The Dobleman Institute, Dobleman Research Award (2011)
Member of the NIH/NIAID Mucosal Immune Studies Team (MIST) and the Steering Committee of the MIST program (2011)
NIH study sections (HBPP, AOIC, HCAC, etc) (2004-2020)

Publications

Complete list of published work on PubMed

Complete list of published work on Scopus

Grants

Current grants

NIH R01-AI116323-07: “Molecular Basis of Intestinal Cryptosporidiosis.” Principal investigator: Dr. Chen
NIH R01-AI136877-04: “LincRNAs in Mucosal Defense to AIDS Opportunistic Pathogen Cryptosporidium.” Principal investigator: Dr. Chen
NIH R21-AI I141325-02: “Intestinal Stem Cell Responses to Cryptosporidium Infection.” Principal investigator: Dr. Chen
NIH R21-AI156370-01: “LncRNA regulation of type I IFN signaling in intestinal epithelium.” Principal investigator: Dr. Chen

Past grants

NIH U01-AI095532 : “Epithelial exosomes and TLR-mediated mucosal defense.” Principal investigator: Dr. Chen
NIH MIST_Pilot : “Epithelial lincRNAs in mucosal antimicrobial defense.” Principal investigator: Dr. Chen
DoD-PC121561 : “LincRNAs and AR reactivation in prostate cancer cells.” Principal investigator: Dr. Chen
NIH R01-DK057993: “Pathophysiology of Biliary Cryptosporidiosis.” Principal investigator: Dr. LaRusso; Co-Investigator: Dr. Chen
NIH R01-AI071321 : “microRNAs in Epithelial Innate Immunity to C. parvum.” Principal investigator: Dr. Chen

Education

Research Areas