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Stefan Green, PhD

Stefan Green, PhD
Associate Professor
Department of Internal Medicine, Division of Infectious Diseases, RUSH Medical College
Director, Core Laboratory Services (Office of Research Affairs)
Director, Genomics and Microbiome Core Facility (Office of Research Affairs)
Education

PhD, Hebrew University of Jerusalem, Israel: Microbiology/Plant Protection
MS, Northwestern University, Illinois: Environmental Health Engineering
BA, Wesleyan University, Connecticut: Earth and Environmental Sciences

Contact Info:

Jelke Building, Room 444
1750 W. Harrison St.
Chicago, IL 60612
Phone: (312) 942-1326
Email: stefan_green@rush.edu
Links:
Biography

Stefan Green, PhD is an Associate Professor in the Department of Internal Medicine, Division of Infectious Diseases, at Rush University, and is also Director of the Genomics and Microbiome Core Facility (GMCF) and Director of Core Lab Services. He is a microbial ecologist and molecular biologist with an emphasis on the interrogation of biological systems through cultivation-independent molecular analyses of DNA and RNA samples. His current research is largely focused on the interactions of complex microbial communities with hosts across a range of experimental and diseases systems, including the study of effects of spaceflight on host-associated microbial communities. Green has over 25 years of experience in research and sequence data acquisition, and has over 175 peer-reviewed publications.

As director of the GMCF, Green has established a shared-resource facility at Rush University performing high-throughput RNA and DNA extractions, next-generation sequencing preparations including high-throughput amplicon sequencing, target capture, whole genome sequencing, shotgun metagenome sequencing, and quantitative PCR analyses. The GMCF also houses the Regional Innovative Public Health Laboratory (RIPHL), a public-academic partnership with the Chicago Department of Public Health (CDPH). In addition, Green serves as Director of Core Laboratory Services, managing all shared resource research facilities at Rush.

Publications

Complete list of published work on PubMed

Complete list of published work on Google Scholar

Grants

Regional Innovative Public Health Services (RIPHL) – Chicago Department of Public Health
The RIPHL aims to advance public health understanding of the transmission and evolution of COVID-19 and other high-consequence pathogens in the Chicago region. The RIPHL will add value to existing clinical, public health and academic laboratories in Chicago through the coordination and combined application of advanced molecular techniques and detailed clinical and epidemiologic data.
Role: co-Principal Investigator

Prebiotics Intervention to Reduce Alzheimer’s Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model – NIH
This study aims to determine if dietary interventions can be used to control gut microbial composition and activity, which may protect brain vascular and metabolic functions, and reduce neuro-inflammation and AD-like pathology of asymptomatic E4FAD mice.
Role: Co-Investigator

Effects of Spaceflight on Gastrointestinal Microbiota in Mice:  Mechanisms and Impact on Multi-System Physiology – NASA
The overall goal of this project is to analyze the effects of space flight, diet and genotype on host gene expression and gut microbiome.
Role: Co-Principal Investigator

Menstrual cups, maturation of the adolescent vaginal microbiome, and STI/HIV risk – NIH
The major goals of this project are to study the mechanisms by which menstrual cup use leads to reduced BV and STIs, and the effect of menstrual cup use on evolution of the adolescent vaginal microbiome, through characterizing the vaginal bacterial microbiome using high throughput amplicon sequencing in a randomly selected sample of 440 girls aged 14-16 years, nested as a longitudinal sub-study within a cluster randomized controlled trial to scale up menstrual cup use among school girls in western Kenya.
Role: Co-Investigator

Successful clinical response in pneumonia therapy (SCRIPT) systems biology center – NIH
The major goals of this project are to study host immune response to pathogens, bacterial factors beyond antibiotic susceptibility, and a failure to restore the lung microenvironment that contribute to the high rates of failure in patients with hospital-acquired pneumonia to identify biomarkers that predict clinical failure.
Role: Co-Investigator