PhD, University of Illinois at Urbana-Champaign
MS, University of Illinois at Urbana-Champaign
BS, University of Illinois at Urbana-Champaign
Ryanodine receptor calcium release channel, calcium signaling
The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor (RyR) Ca release channel in excitable cells. These control mechanisms are fundamental to many cellular phenomena and, thus, are often sites of pathological failure and potential targets for therapeutic intervention.
Dr. Fill’s laboratory at Rush University is internationally recognized for its world-class RyR experimental expertise. The Ca signals generated by RyRs are known to modulate a myriad of physiological functions. Our lab details clinically significant structure-function attributes of single RyR function in health and disease, including local RyR control by Ca, closely regulatory proteins and post-translational modifications. This provides a strong mechanistic foundation for our group’s ongoing work toward developing new RyR-targeted drugs that will hopefully be applied to limit/treat diseases exacerbated or caused by hyperactive RyR Ca signaling.
Complete list of published work on PubMed
Complete list of published work on Scopus
Chen … Fill, et al. “RyR store-sensing gate controls C waves and C-triggered arrhythmias.” Nature Medicine. 20(2): 184-92, 2014.
Zhou … Fill, et al. “Carvedilol and its new analogs suppress arrhythmogenic … Ca release.” Nature Medicine. 10;17(8): 1003-9, 2011.
Fill and Copello. “RyR Ca release channels.” Physiological Reviews. 82(4): 893-922, 2002.
Minn … Fill, et al. “Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms.” EMBO Journal. 1;18(3): 632-43, 1999.
Minn, et al. and Fill. “Bcl-x(L) forms an ion channel in synthetic lipid membranes.” Nature. 23;385(6614): 353-7, 1997.
Cheng, Fill et al. “Models of Ca release channel adaptation.”Science. 267(5206): 2009-10, 1995.
Györke and Fill. “Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart.” Science. 7;260(5109): 807-9, 1993.
Ma, Fill et al. “Ryanodine receptor of skeletal muscle is a gap junction-type channel.” Science. 7;242(4875): 99-102, 1988.