MD, Rush Medical College
Residency, Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center
Fellowship, Infectious Diseases, Rush-Presbyterian-St. Luke's Medical Center
Hospital Epidemiology, bone and joint infections, blood stream infections, antibiotic utilization and hospital-acquired infections.
Research Areas:
Hospital Epidemiology, prevention of hospital-acquired infections
File TM, Segreti, J, Dunbar L, Player R, Kohler R, Williams RR, Kojak C and Rubin A. Multicenter, Randomized Study Comparing the Efficacy and Safety of IV and/or Oral Levofloxacin versus Ceftriaxone and/or Cefuroxime Axetil in the Treatment of Adults with Community-Acquired Pneumonia. Antimicrobial Agents in Chemotherapy. 1997;41(9)
Segreti J, Nelson JA, Trenholme GM. Chronic Antibiotic Suppression for Infected Orthopedic Prostheses. Clinical Infectious Diseases. 1998; 27:711-713
Segreti J. Efficacy of Current Agents Used in the Treatment of Gram-positive Infections and the Consequences of Resistance. Clin Microbiol Infect. 2005 May;11 Suppl 3:29-35.
Finney MS, Crank CW, and Segreti J. Use of Daptomycin to Treat Drug-Resistant Gram-Positive Bone and Joint Infections. Current Medical Research and Opinions 2005 21:1923-1926
Segreti J, House HR, and Siegel RE. Principles of Antibiotic Treatment of Community-acquired Pneumonia in the Outpatient Setting. Am J Med. 2005 Jul;118 Suppl 7A:21S-28S.
Turner TM, Urban RM, Hall DJ, Chye PC, Segreti J, Gitelis S. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res. 2005 Aug;(437):97-104.
Segreti JA, Crank CW, Finney MS. Daptomycin for the treatment of gram-positive bacteremia and infective endocarditis: a retrospective case series of 31 patients. Pharmacotherapy. 2006 Mar;26(3):347-52.
Segreti J. Empirical therapy for serious Gram-positive infections: making the right choice. Clin Microbiol Infect. 2009 Dec;15 Suppl 6:5-10
Chihara S, Segreti J. Osteomyelitis. Disease-a- Month. 2010 Jan;56(1):5-31.
Della Valle C, Parvizi J, Bauer TW, Dicesare PE, Evans RP, Segreti J, Spangehl M, Watters WC 3rd, Keith M, Turkelson CM, Wies JL, Sluka P, Hitchcock K; American Academy of Orthopaedic Surgeons. Diagnosis of Periprosthetic Infections of the Hip and Knee. J Am Acad Orthop Surg. 2010 Dec;18(12):760-70
Crank CW, Scheetz MH, Brielmaier B, Rose WE, Patel GP, Ritchie DJ, Segreti J. Comparison of outcomes from daptomycin or linezolid treatment for vancomycin-resistant enterococcal bloodstream infection: A retrospective, multicenter, cohort study. Clin Ther. 2010 Sep;32(10):1713-9.
Segreti J, Garcia-Houchins S, Gorski L, Moureau N, Shomo J, Zack J, Stachnik J, Tanzi M, Moody ML. Consensus Conference on Prevention of Central Line-Associated Bloodstream Infection.. J Infus Nurs. 2011 March/April;34(2):126-133.
Della Valle C, Parvizi J, Bauer TW, DiCesare PE, Evans RP, Segreti J, Spangehl M, Watters WC 3rd, Keith M, Turkelson CM, Wies JL, Sluka P, Hitchcock K. American Academy of Orthopaedic Surgeons clinical practice guideline on: the diagnosis of periprosthetic joint infections of the hip and knee. American Academy of Orthopaedic Surgeons. J Bone Joint Surg Am. 2011 Jul 20;93(14):1355-7.
Segreti J, Jones RN, Bertino JS Jr. Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones. J Ocul Pharmacol Ther. 2012 Feb;28(1):3-11
Casapao AM, Kullar R, Davis SL, Levine DP, Zhao JJ, Potoski BA, Goff DA, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ. Multicenter study of high-dose daptomycin for treatment of enterococcal infections. Antimicrob Agents Chemother. 2013 Sep;57(9):4190-6.
Tetreault MW, Wetters NG, Aggarwal VK, Moric M, Segreti J, Huddleston JI 3rd, Parvizi J, Della Valle CJ. Should draining wounds and sinuses associated with hip and knee arthroplasties be cultured? J Arthroplasty. 2013 Sep;28(8 Suppl):133-6.
Kullar R, Casapao AM, Davis SL, Levine DP, Zhao JJ, Crank CW, Segreti J, Sakoulas G, Cosgrove SE, Rybak MJ. A multicentre evaluation of the effectiveness and safety of high-dose daptomycin for the treatment of infective endocarditis.J Antimicrob Chemother. 2013 Dec;68(12):2921-6
Rao SN, Rhodes NJ, Lee BJ, Scheetz MH, Hanson AP, Segreti J, Crank CW, Wang SK. Treatment outcomes with cefazolin versus oxacillin for deep-seated methicillin-susceptible Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother. 2015 Sep;59(9):5232-8. doi: 10.1128/AAC.04677-14. Epub 2015 Jun 15. Erratum in: Antimicrob Agents Chemother. 2015 Nov;59(11):7159.
VanEperen AS, Segreti J. Empirical therapy in Methicillin-resistant Staphylococcus Aureus infections: An Up-To-Date approach. J Infect Chemother. 2016 Jun;22(6):351-9
Frank JM, Kayupov E, Moric M, Segreti J, Hansen E, Hartman C, Okroj K, Belden K, Roslund B, Silibovsky R, Parvizi J, Della Valle CJ; Knee Society Research Group. The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial. Clin Orthop Relat Res. 2017 Jan;475(1):56-61
Segreti J, Parvizi J, Berbari E, Ricks P, Berríos-Torres SI. Introduction to the Centers for Disease Control and Prevention and Healthcare Infection Control Practices Advisory Committee Guideline for Prevention of Surgical Site Infection: Prosthetic Joint Arthroplasty Section. Surg Infect (Larchmt). 2017 May/Jun;18(4):394-400.
Berbari E, Segreti J, Parvizi J, Berríos-Torres SI. Future Research Opportunities in Peri-Prosthetic Joint Infection Prevention. Surg Infect (Larchmt). 2017 May/Jun;18(4):409-412
Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, Reinke CE, Morgan S, Solomkin JS, Mazuski JE, Dellinger EP, Itani KMF, Berbari EF, Segreti J, Parvizi J, Blanchard J, Allen G, Kluytmans JAJW, Donlan R, Schecter WP; Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017 May 3.