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João Mamede, PhD

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João Mamede, PhD

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Assistant Professor, Department of Microbial Pathogens and Immunity

RUSH Medical College

Assistant Professor, Department of Microbial Pathogens and Immunity

Contact Information

Address: 1735 W. Harrison St., Suite 612 (Cohn Building)
Chicago, IL 60612
Phone:
(312) 563-9411
Email:
joao_mamede@rush.edu

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Research Profile

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PhD, Molecular Biology and Virology, University of Montpellier 1, France
BS, Biochemistry, University of Coimbra, Portugal
João Mamede, PhD, studies the interactions between viruses and their adaptations to their hosts. Mamede earned his PhD in virology and molecular biology on his studies on cellular proteins that play an important role in the infection of circulating SIV from different monkey species and HIV-2 from a cohort of patients.

His postdoctoral and current focus of research is on the study of the HIV mechanisms of infection in cell lines, CD4 T-cells, macrophages,and dendritic cells. Mamede is interested in studying the intracellular innate immunity mechanisms, cellular responses and cellular adaptations to incoming viral particles. His research program has special interest in proteins that are regulated by Interferon (interferon stimulated genes) and how their expression promotes or blocks infectivity.

Mamede has used multiple techniques, such as long live-cell fluorescence imaging, high and super resolution fixed immunofluorescence (3D-SIM), biochemistry, biophysical, quantitative PCR, flow cytometry, and functional assays, to study lentiviral infections of HIV-1, HIV-2, and SIVs from multiple non-human primates.
- K22 AI140963: Direct Live-Cell Visualization and Quantification of Interactions Between Infectious HIV Particles in Primary Target Cells
- CHEETAH Center Development Award: Study of the Early-steps of the HIV Replication Cycle of Infectious HIV Particles (Sub-Contract From P50 AI150464)

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