COVID-19 Rush Journal Club Archives - By Date

Browse all articles reviewed by date below, or visit this page to view the current edition containing all reviews.

August 13, 2020

This week we are switching to a new format with our journal. We have reviewed over 250 articles(!) about COVID-19 and to improve usability we will be dividing our journal into sections. We will leave up a link to our full journal updated to 8/6, but moving forward we will publish shorter topic specific collections.

Today that will include new articles in Treatment and Pathogenesis:

Treatment

Optimizing Hydroxychloroquine Dosing for Patients With COVID-19: An Integrative Modeling Approach for Effective Drug Repurposing (Review by Abigail Bawden, MS2)
Tocilizumab for the treatment of severe coronavirus disease 2019 (Review by Monique Holod, MS1)

Pathogenesis

Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Ischemic Stroke (Review by Carter Do, MS1)
Incidence of thrombotic complications in critically ill ICU patients with COVID-19 (Review by Alexander Hodakowski, MS1)

August 6, 2020

We are featuring a number of new reviews this week in the Rush COVID-19 Journal Club. We would especially like to highlight the additions to our Public Health section which features new articles focusing on the racial disparities caused by the COVID-19 epidemic. These articles, as well as others we have previously reviewed, are also featured in this week’s social media post which you can find on instagram @rmc_covidjournal.

The full list of added articles is below:

Biology

SARS-CoV-2 infection protects against rechallenge in rhesus macaques (Review by Abigail Bawden, MS2)
Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts (Review by Abigail Bawden, MS2)

A pneumonia outbreak associated with a new coronavirus of probable bat origin (Review by Abigail Bawden, MS2)

Treatment

Case reports study of the first five patients COVID-19 treated with remdesivir in France (Review by Carter Do, MS1)
Early Outcomes with Utilization of Tissue Plasminogen Activator in COVID-19 Associated Respiratory Distress: A Series of Five Cases (Review by Melissa Porterhouse, MS1)
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19) (Review by Aliya Rodriguez, MS1)

Critical Care

Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in Coronavirus Disease 2019: Experience with 32 Patients (Review by Reilly Frauchiger-Ankers, MS1)

Public Health

Spatial analysis of COVID-19 clusters and contextual factors in New York City. (Review by Ashley Wehrheim, MS3)
The association of race and COVID-19 mortality (Review by Ashley Wehrheim, MS3)
The impact of ethnicity on clinical outcomes in COVID-19: A systematic review (Review by Ashley Wehrheim, MS3

Have a great end to the week everyone, stay safe and masked up!

July 31, 2020

We are featuring new reviews today in the fields of public heath and pathogenesis. Several of these reviews are featured in our latest social media post about schools. You can check out the post today and our previous post about masks on Instagram by following us @rmc_covidjournal.

We also want to welcome the newest cohort of Rush Medical students who have joined up to help us write reviews before they start classes this fall.

The reviews added this week are:

Public Health

Economic Vulnerability of Households With Essential Workers (Review by Mohammed Abdul Sami, M1)

Pathogenesis

COVID-19: unanswered questions on immune response and pathogenesis (Review by Mohammed Abdul Sami, M1)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review (Review by Abigail Bawden, MS2)
SARS-CoV-2 Infection in Children (Review by Leah Greenfield, MS2)
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents (Review by Mohammed Abdul Sami, M1)

July 24, 2020

We are back with the Rush Covid-19 Journal Club!

We have also started a new social media arm which will be publishing weekly updates on major topics. You can follow our Instagram @rmc_covidjournal and see our first post on mask usage!

Today we are adding one review in the field of Pathogenesis:

Pathogenesis

Covid-19 in Critically Ill Patients in the Seattle Region - Case Series (Review by Carter Do, MS1)

June 29, 2020

We are featuring five new articles in the important field of Public Health. Articles focus on the use of masks for the prevention of transmission of COVID-19 and the social disparities being laid bare by the pandemic.

Public Health

To mask or not to mask: Modeling the potential for face mask use by the general public to curtail the COVID-19 Pandemic. (Review by Kaitlyn Wehrheim, MS3)
Associations between Built Environment, Neighborhood, Socioeconomic Status, and SARS-CoV-2 Infection among Pregnant Women (Review by Ashley Wehrheim, MS3)
The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission (Review by Bijan Zarrabi, MS2)
A rapid systematic review of the efficacy of face masks and respiratory against coronavirus and other respiratory transmissible Viruses (Review by Ashley Wehrheim, MS3)
Hospitalization and Mortality among Black Patients and White Patients with Covid-19 (Review by Ashley Wehrheim, MS3)

June 26, 2020

Today we are featuring another article on the use of Hydroxychloroquine as well as an article about COVID-19 in the Latinx population which provides us with an important reminder of the disproportionate effect this virus has had on communities of color in the United States.

Treatment

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for COVID-19 (Review by Dallas Kramer, MS4)

Public Health

SARS-CoV-2 Positivity Rate for Latinos in the Baltimore-Washington, DC Region (Review by Ashley Wehrheim, MS3)

June 22, 2020

Today we are featuring an article with another perspective on the use of RAAS inhibiting medications in patients with COVID-19.

Treatment

SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19? (Review by Abigail Bawden, MS1)

June 19, 2020

This Friday we are featuring an article about vaccine development in animal models for SARS-CoV-2:

Vaccine Development

ChAdOxI nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (Review by Leah Greenfield, MS1)

June 18, 2020

Today we are featuring a new article in Diagnosis and measurement of antibodies for COVID-19:

Diagnosis

Diagnostic Accuracy of an Automated Chemiluminescent Immunoassay for anti-SARS-CoV-2 IgM and IgG Antibodies: An Italian Experience (Review by Emily He, MS4)

June 16, 2020

We are featuring one new article today:

Vaccine Development

DNA vaccine protection against SARS-CoV-2 in rhesus macaques (Review by Leah Greenfield, MS1)

June 15, 2020

We are featuring a new review today about the postmortem findings of pt with COVID-19:

Pathogenesis

Postmortem Examination of Patients With COVID-19 (Review by Kelly Harmon, MS1)

June 10, 2020

We are featuring one new review today:

Critical Care

Initial Clinical Impressions of the Critical Care of COVID-19 Patients in Seattle, New York City, and Chicago. (Review by Nick Sytsma, MD)

June 8, 2020

One new featured study to start the week:

Epidemiology

Estimating the Infection Fatality Rate Among Symptomatic COVID-19 Cases in the United States (Review by Alexandria Taphorn, MS3)

June 5, 2020

Only one new study featured this Friday, and some updates made to our journal including noting the retraction of the recent NEJM study “Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19.” It was retracted due to the same issue as the prior Lancet study. They both relied on a data set that they could not independently verify. Read the statement from NEJM

Pathogenesis

High Fluorescent Lymphocytes Are Increased in COVID-19 Patients (Review by Kelly Harmon, MS1)

June 4, 2020

We are featuring three new studies today.

We also have made a note that The Lancet study entitled “Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis” originally published May 22, 2020 was retracted today (June 4) after the authors determined they could not independently audit the registry data. Our review remains with a note that it was retracted and the date. Read their statement

Treatment

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19) (Review by Steven Heidt, MD)
Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State (Review by Steven Heidt, MD & Hannah Raff, MS4)

Pathogenesis

Viral and host factors related to the clinical outcome of COVID-19 (Review by Kelly Harmon, MS1)

June 3, 2020

Today we have three new featured articles, including one focused on a concerning side effect of Hydroxychloroquine/Chloroquine use.

Public Health

Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 (Review by Kat Tehaney, MS1)

Treatment

Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit (Review by Steven Heidt, MD)

Pathogenesis

Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia (Review by Kevin Grudzinski, MS2)

June 2, 2020

Today’s journal club has added three new articles:

Pathogenesis

Pulmonary embolism in COVID-19 patients: Awareness of an increased prevalence (Review by Samantha Betman, MS3)

Public Health

Diabetes and COVID-19: Psychosocial Consequences of the COVID-19 Pandemic in People With Diabetes in Denmark-what Characterizes People With High Levels of COVID-19-related Worries? (Review by Kat Tehaney, MS1)
An interpretable mortality prediction model for COVID-19 patients (Review by Kat Tehaney, MS1)

June 1, 2020

We are featuring three new articles in our Journal Club today:

Biology

A multi-basic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells (Review by Luke McCormack, MS2)

Public Health

Quarantine alone or in combination with other public health measures to control COVID‐19: a rapid review (Review by Kelly Harmon, MS1)
Internet Searches for Unproven COVID-19 Therapies in the United States (Review by Kat Tehaney, MS1)

May 30, 2020

Our Journal Club today covers some important articles in Treatment and Epidemiology. We cover updated guidelines from the Infectious Diseases Society of America as well as the recent registry analysis of Hydroxychloroquine/Chloroquine treatment from The Lancet.

Note: If you view the journal in PDF format, the hyperlinks will be functional whether you view it in a browser window or saved to your computer. This view also allows use of Control+F to search the document for keywords and phrases.

Today’s studies:

Treatment

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 (Review by Emily Chi, MS3)
Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis (Review by Joseph deBettencourt, MS3)
Tocilizumab for Treatment of Severe COVID-19 Patients: Preliminary Results from SMAtteo COvid19 REgistry (SMACORE) (Review by Kavya Timmireddy, MS3)
Myth Busters: Dietary Supplements and COVID-19 (Review by Joseph deBettencourt, MS3)

Epidemiology

Comparison of estimated rates of coronavirus disease 2019 (COVID-19) in border counties in Iowa without a stay-at-home order and border counties in Illinois with a stay-at-home order (Review by Antonios Skondras, MS2)

May 29, 2020

We are excited to get back to our daily publishing schedule for the Rush COVID-19 Journal Club. Today we have one new article but many more updates are to come, so please continue to check in with us!

New today in Biology:

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors (Review by Steven Heidt, MD)

May 23, 2020

Two new articles this weekend, one covering a new study of Hydroxychloroquine and another focusing on COVID-19 in the prison system here in the U.S.

Treatment

Observational study of hydroxychloroquine in hospitalized patients with COVID-19. (Review by Kavya Timmireddy, MS3)

Public Health

COVID-19 in Prisons and Jails in the United States. (Review by Alice Burgess, MS2)

May 22, 2020

Before the long weekend we wanted to make a quick update to our journal with our 200th review!

Pathogenesis

Virological assessment of hospitalized patients with COVID-2019 (Review by Rob DeStefano, MD)

May 21, 2020

We have four new reviews today in the following topic areas:

Epidemiology

Clinical characteristics of patients hospitalized with coronavirus disease, Thailand. (Review by Natalie Maltby MS1)

Public Health

Mental Health Status Among Children in Home Confinement During the Coronavirus Disease 2019 Outbreak in Hubei Province, China. (Review by Kat Tehaney, MS1)
Geographic Differences in COVID-19 Cases, Deaths, and Incidence - United States, February 12-April 7, 2020 (Review by Eiftu Haile, MD)

Critical Care

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19 (Review by Nick Sytsma, MD)

May 20, 2020

We have added nine new reviews today. They cover three different topic areas with contributions from every class at Rush Medical College.

Pathogenesis

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. (Review by Rob DeStefano, MD)
Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study. (Review by Kaitlyn Wehrheim, MS2)
D-Dimer Levels on Admission to Predict In-Hospital Mortality in Patients with Covid-19. (Review by Samantha Betman, MS3)
Endothelial cell infection and endotheliitis in COVID-19. (Review by Kevin Grudzinski, MS2)

Public Health

COVID-19 and smoking: A systematic review of the evidence. (Review by Kelly Harmon, MS1 )
Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. (Review by Kelly Harmon, MS1 )
Does Comorbidity Increase the Risk of Patients With COVID-19: Evidence from Meta-Analysis. (Review by Kelly Harmon, MS1 )
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study. (Review by Kat Tehaney, MS1)

Treatment

Clinical Efficacy of Lopinavir/Ritonavir in the Treatment of Coronavirus Disease 2019. (Review by Manvita Tatavarthy, MS2)

May 19, 2020

Today we have added seven new reviews covering the following areas:

Diagnosis

Ultrastructural evidence for direct renal infection with SARS-CoV-2. (Review by Hannah Raff, MS3)

Treatment

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19. (Review by Joseph deBettencourt, MS3)
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study. (Review by Ashley Wehrheim, MS2)
Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. (Review by Ashley Wehrheim, MS2)

Epidemiology

Changes in SARS-CoV-2 positivity rate in outpatients in Seattle and Washington state, March 1-April 16, 2020. (Review by Antonios Skondras MS2)
Thinking Globally, Acting Locally—The U.S. Response to Covid-19. (Review by Ritika Dhawan, MD)
Coronavirus disease outbreak in call center, South Korea. (Review by Antonios Skondras, MS2)

May 18, 2020

This week we welcome a new team of student Editors in Chief as we look forward to the next academic year at Rush University! We are featuring three new literature reviews today:

Public Health

Variation in COVID-19 Hospitalizations and Deaths Across New York City Boroughs. (Review by Josh Doppelt, MD)
Impact of school closures for COVID-19 on the US health-care workforce and net mortality: a modeling study. (Review by Kat Tehaney, MS1)
Awareness, Attitudes, and Actions Related to COVID-19 Among Adults with Chronic Conditions at the Onset of the U.S. Outbreak. (Review by Timothy Huang, MS1)

May 17, 2020

New today: The “Treatment” section has now been divided by therapy for ease of use. Reviews covered the following 3 studies:

Vaccine Development

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. (Review by Yereida Gallardo, MS1)

Treatment

Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. (Review by Maria Amir, MS2)
Current evidence for directed and supportive investigational therapies against COVID-19. (Review by Christi Brown, MS2)

May 16, 2020

New reviews today covered the following 4 studies:

Epidemiology

Community transmission of SARS-CoV-2 at two family gatherings—Chicago, Illinois, February - March 2020. (Review by Natalie Maltby, MS1)
Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. (Review by Steven Heidt, MD)
The association between international and domestic air traffic and the coronavirus (COVID-19) outbreak. (Review by Elena Perkins, MS3)

Critical Care

Cardiovascular disease, drug therapy, and mortality in Covid-19. (Review by Nick Sytsma, MD)

May 15, 2020

Today’s reviews covered the following 4 studies:

Pathogenesis

The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. (Review by Adithya Sivakumar, MS1)
Acute Hyperglycemic crises with coronavirus disease-19: Case reports. (Review by Al Hornung, MS1)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: A systematic review. (Review by Samantha Betman, MS3)

Treatment

COVID-19 infection and rheumatoid arthritis: Faraway, so close! (Review by Danesha Lewis, PhD student)

May 14, 2020

New reviews today covered the following 4 studies:

Pathogenesis

Dysregulation of immune response in patients with COVID-19 in Wuhan, China. (Review by Kaitlyn Wehrheim, MS2)
Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state. (Review by Samantha Betman, MS3)
Renin-angiotensin-aldosterone system blockers and the risk of Covid-19. (Review by Dallas Kramer, MS3)
A dynamic immune response shapes COVID-19 progression. (Review by Al Hornung, MS1)

May 13, 2020

New reviews today covered the following 4 studies:

Treatment

Traditional Chinese and Western Medicines Jointly Beat COVID-19 Pandemic.(Review by Sarah Sun, MS2)
Efficacy and safety of lopinavir/ritonavir or arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial. (Review by Demetrios Geanon, MS3)
Tocilizumab for the Treatment of Severe COVID‐19. (Review by Amanda Narkis, MS2)
Vaccines for SARS-CoV-2: Lessons from Other Coronavirus Strains. (Review by Ahmad Gill, MS3)

May 12, 2020

New reviews today covered the following 6 studies:

Epidemiology

Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. (Review by Gary Wu, MS3)
SARS-CoV-2 infection (COVID-19) in febrile infants without respiratory distress. (Review by Bryant Yu, MS3)
Demographic science aids in understanding the spread and fatality rates of COVID-19 (Review by Steven Heidt, MD)
Identifying and interrupting superspreading events—implications for control of severe acute respiratory syndrome coronavirus 2. (Review by Natalie Maltby, MS1)
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area (Review by Elena Perkins, MS3)

Diagnosis

Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019. (Review by Kelsey Danley, MD)

May 11, 2020

New reviews today covered the following 6 studies:

Biology

Phylogenetic network analysis of SARS-CoV-2 genomes. (Review by Emily Hejna, MS2)

Epidemiology

Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions. (Review by Susan Mari, MS2)

Pathogenesis

Elevated interleukin-6 and severe COVID-19: A meta-analysis. (Review by Dallas Kramer, MS3)
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). (Review by Dallas Kramer, MS3)
SARS-CoV-2 and Viral Sepsis: Observations and Hypothesis. (Review by Kaitlyn Wehrheim, MS2)
Renin-angiotensin-aldosterone system inhibitors and risk of COVID-19. (Review by Robert DeStefano, MD)

May 10, 2020

New reviews today covered the following 4 studies:

Diagnosis

Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. (Review by Emily He, MS3)
A preliminary study on the ultrasonic manifestations of peripulmonary lesions of non-critical novel coronavirus pneumonia (COVID-19). (Review by Nick Sytsma, MD)

Epidemiology

Association of Public Health Interventions with the Epidemiology of the COVID-19 Outbreak in Wuhan, China. (Review by Steve Heidt, MD)

Treatment

Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). (Review by Joseph deBettencourt, MS3)

May 9, 2020

New reviews today covered the following 5 studies:

Epidemiology

Clinical characteristics of pregnant women with Covid-19 in Wuhan, China. (Review by Bryant Yu, MS3)

Public Health

Contact Tracing Assessment of COVID-19 Transmission Dynamics in Taiwan and Risk at Different Exposure Periods Before and After Symptom Onset. (Review by Josh Doppelt, MD)
First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment. (Review by Josh Doppelt, MD)

Treatment

Letter to the Editor: Acute hypertriglyceridemia in patients with COVID‐19 receiving tocilizumab. (Review by Amanda Narkis, MS2)
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. (Review by Ashley Wehrheim, MS2)

May 8, 2020

Reviews today covered the following 5 studies:

Epidemiology

Cardiovascular disease, drug therapy, and mortality in COVID-19. (Review by Kavya Timmireddy, MS3)

Pathogenesis

Inhibitors of the renin–angiotensin system: The potential role in the pathogenesis of COVID-19. (Review by Clara Ledsky, MS2)
Guillain-Barre syndrome associated with SARS-CoV-2. (Review by Mira Marchioretto, MS2)
COVID-19 Coagulopathy in Caucasian patients. (Review by Al Hornung, MS1)

Treatment

Off‐label use of tocilizumab in patients with SARS‐CoV‐2 infection. (Review by Maria Amir, MS2)

May 7, 2020

Review for today covered the following 6 studies:

Pathogenesis

Acute kidney injury in SARS-CoV-2 infected patients. (Review by Megan Kotzin, MS1)
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19. (Review by John Levinson, MS2)
Alterations in Smell or Taste in Mildly Symptomatic Outpatients with SARS-CoV-2 Infection. (Review by Kevin Grudzinski, MS2)

Treatment

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. (Review by Maria Amir, MS2)

Vaccine Development

Epitope-based peptide vaccine design and target site characterization against novel coronavirus disease caused by SARS-CoV-2. (Review by Sharice Hall, MS1)

Infection Control/Prevention

SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. (Review by Samantha Betman, MS3)

May 6, 2020

New reviews today covered the following 10 studies:

Epidemiology

Factors associated with prolonged viral RNA shedding in patients with COVID-19. (Review by Elena Perkins, MS3)

Pathogenesis

Gastrointestinal manifestation of SARS-CoV_2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. (Review by Kelly Harmon, MS1)
Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword? (Review by Dallas Kramer, MS3)
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. (Review by Megan Kotzin, MS1)
Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19. (Review by Al Hornung, MS1)
Complex immune dysregulation in COVID-19 patients with severe respiratory failure. (Review by Al Hornung, MS1)

Treatment

Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. (Review by Maria Amir, MS2)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. (Review by Ashley Wehrheim, MS2)

Vaccine Development

Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies. (Review by Pranita Kaginele, MS2)
Strategies for vaccine design for corona virus using Immunoinformatics techniques. (Review by Audrey Sung, MS3)

May 5, 2020

Reviews today covered the following 9 studies:

Biology

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. (Review by Ndubisi Onah, MS3)

Epidemiology

A systematic review of COVID-19 epidemiology based on current evidence. (Review by Kelly Harmon, MS1)
Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. (Review by Steven Heidt, MD)
Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. (Review by Gary Wu, MS3)

Pathogenesis

Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. (Review by Al Hornung, MS1)
Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. (Review by Rob DeStefano, MD)

Critical Care

Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic. (Review by Nick Sytsma, MD)

Treatment

Chloroquine and hydroxychloroquine in covid-19. (Review by Amanda Narkis, MS2)
Flooded by the torrent: The COVID-19 drug pipeline. (Review by Joseph deBettencourt, MS3)

Vaccine Development

Insights into cross-species evolution of novel human coronavirus 2019-nCoV and defining immune determinants for vaccine development. (Review by Yereida Gallardo, MS1)

May 4, 2020

Today’s reviews cover the following 9 studies:

Public Health

Perceptions and behavioural responses of the general public during the COVID-19 pandemic: Cross-sectional survey of UK adults. (Review by Katherine Tehaney, MS1)

Epidemiology

The impact of nutrition on COVID-19 susceptibility and long-term consequences.(Review by Alice Burgess, MS2)
Asymptomatic SARS-CoV-2 infection in household contacts of a healthcare provider, Wuhan, China. (Review by Antonios Skondras, MS2)
High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. (Review by Grace Alexander, MS2)

Diagnosis

Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19). (Review by Kelsey Danley, MD)
Evaluation of Nucleocapsid and spike protein-based ELISAs for detecting antibodies against SARS-CoV-2. (Review by Paul Parker, MD)

Treatment

Creating a framework for conducting randomized clinical trials during disease outbreaks. (Review by Ayesan Rewane, MSCR)
Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A review. (Review by Sarah Sun, MS2)

Vaccine Development

Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus. (Review by Johanna Balas, MS1)

May 3, 2020

Today’s reviews cover the following 7 studies:

Public Health

A Brief Telephone Severity Scoring System and Therapeutic Living Centers Solved Acute Hospital-Bed Shortage during the COVID-19 Outbreak in Daegu, Korea. (Review by Josh Doppelt, MD)
The Untold Toll—The Pandemic’s Effects on Patients without Covid-19. (Review by Laura Hurley, MS3)

Pathogenesis

Cardiovascular complications in patients with COVID-19: Consequences of viral toxicities and host immune response. (Review by Kaitlyn Wehrheim, MS2)
Reduction and functional exhaustion of t cells in patients with coronavirus disease 2019 (COVID-19). (Review by Kaitlyn Wehrheim, MS2)
Cardiovascular disease and COVID-19. (Review by John Bretzman, MD)

Treatment

Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19. (Review by Demetrios Geanon, MS3)

Vaccine Development

If a coronavirus vaccine arrives, can the world make enough? (Review by Morgan Sturgis, MS2)

May 2, 2020

Today’s reviews cover the following 6 studies:

Pathogenesis

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor (Review by John Bretzman MD)
Human leukocyte antigen susceptibility map for SARS-CoV-2 (Review by Sameera Khan, MS1)
Virology, epidemiology, pathogenesis, and control of COVID-19 (Review by Mira Marchioretto, MS2)
SARS-CoV-2 infection in pregnancy - A review of the current literature and possible impact on maternal and neonatal outcome (Review by Kaitlyn Wehrheim, MS2)
Clinical course and outcomes of patients with severe acute respiratory syndrome coronavirus 2 infection: A preliminary report of the first 28 patients from the Korean cohort study on COVID-19 (Review by Kelly Harmon, MS1)
Liver injury during highly pathogenic human coronavirus infections (Review by Bijan Zarrabi, MS2)

May 1, 2020

Today’s reviews cover the following 9 studies:

Epidemiology

Universal Screening for SARS-CoV-2 in Women Admitted for Delivery (Review by Alice Burgess, MS2)
Duration for carrying SARS-CoV-2 in COVID-19 patients (Review by Bryant Yu, MS2)
Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study (Review by Steven Heidt, MD)

Pathogenesis

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes (Review by Danesha Lewis, PhD student)

Treatment

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases (Review by Alex Hornung, MS1)
Experimental treatment with favipiravir for COVID-19: an open-label control study (Review by Karina Oelerich, MS2)

Vaccine Development

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients (Review by Leah Greenfield, MS1)
In silico Design of novel Multi-epitope recombinant Vaccine based on Coronavirus surface glycoprotein (Review by Ahmad Gill, MS3)
Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein (Review by Yereida Gallardo, MS1)

April 30, 2020

New reviews today looked at the following 15 studies:

Pathogenesis

Characteristics and mechanism of liver injury in 2019 coronavirus disease (Sameera Khan, MS1)

Diagnosis

Clinical Characteristics of Coronavirus Disease 2019 in China (Review by Andy Wu, MS2)
Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: A multicenter study (Review by Ahmet Sakiri, MS2)

Pathology

Pathological findings of COVID-19 associated with acute respiratory distress syndrome (Review by Alex Hornung, MS1)
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model (Review by John Levinson, MS2)

Treatment

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) (Review by Eric Moyer, MD)
Effectiveness of convalescent plasma therapy in severe COVID-19 patients (Review by Ashley Wehrheim, MS2)
Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection (Review by Sarah Sun, MS2)
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial (Review by Joseph deBettencourt, MS3)
Prevention and Therapy of COVID-19 via Exogenous Estrogen Treatment for Both Male and Female Patients; An Opinion Paper (Review by Ashley Wehrheim, MS2)
Management of COVID-19 Respiratory Distress (Review by Eric Moyer, MD)
Effective treatment of severe COVID-19 patients with tocilizumab (Review by Ashley Wehrheim, MS2)
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial (Review by Eric Moyer, MD)
Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea (Review by Christina Brown, MS2)
Some Drugs for COVID-19 (Review by Demetrios Geanon, MS3)

April 29, 2020

Reviews from yesterday and today cover the following 13 items:

Biology

Structure of the RNA-dependent RNA Polymerase from COVID-19 Virus (Review by Ndubisi Onah, MS3)
Is low alveolar type II cell SOD3 in the lungs of elderly linked to the observed severity of COVID-19? (Review by Jackie Urban, MS4)
Visualizing speech-generated oral fluid droplets with laser light scattering (Review by Khatcher Margossian, MS2/PhD student)
A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV (Review by Luke McCormack, MS2)

Epidemiology

Temporal dynamics in viral shedding and transmissibility of COIVD-19 (Review by Steven Heidt, MS4)
Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 – COVID-NET, 14 States, March 1-30, 2020 (Review by Elena Perkins, MS3)
Epidemiology of COVID-19 among children in China (Review by Grace Alexander, MS2)
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak (Review by Alice Burgess, MS2)
Mathematical model of infection kinetics and its analysis for COVID-19, SARS and MERS (Review by Travis Tran, MS2)

Pathogenesis

Description and proposed management of the acute COVID-19 cardiovascular syndrome (Review by Adithya Sivakumar, MS1)

Critical Care

Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience (Review by Nick Sytsma, MS4)
Practical considerations for performing regional anesthesia: lessons learned from the COVID-19 pandemic (Review by John Sweeney, MS3)

Treatment

Compassionate use of remdesivir for patients with severe Covid-19 (Review by Ayesan Rewane, MSCR)

April 27, 2020

New reviews today addressed the following 11 studies:

Public Health

COVID-19 and African Americans (Review by Eiftu Haile, MS4)

Pathogenesis

Evidence for gastrointestinal infection of SARS-CoV-2 (Review by Alex Hornung, MS1)
Rates of co-infection between SARS-CoV-2 and other respiratory pathogens (Review by Kevin Grudzinski, MS2)
Liver injury in COVID-19: Management and challenges (Review by Dallas Kramer, MS3)

Critical Care

COVID-19 Infection Implications for Perioperative and Critical Care Physicians (Review by Beth Hall, MS4)

Diagnosis

COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals (Review by Wendy Tian, MS4)
Profiling early humoral response to diagnose novel coronavirus disease (COVID-19) (Review by Hannah Raff, MS3)

Treatment

Evaluation of Antiviral Therapies for Coronavirus Disease 2019 (COVID‐19) Pneumonia in Shanghai, China. (Review by Athena Jane Manatis-Lornell MS1)
A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19) (Review by Joseph deBettencourt, MS3)

Vaccine Development

Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic (Review by Morgan Sturgis, MS2)
Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus in China (SARS-CoV-2) (Review by Audrey Sung, MS3)

April 26, 2020

New reviews today addressed the following 13 studies:

Biology

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2 (Review by Alexandra Feldner, MS3)
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV (Review by Abigail Bawden, MS1)
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (Review by Luke McCormack, MS2)
Structure of Mpro from COVID-19 virus and discovery of its inhibitors (Review by Luke McCormack, MS2)

Pathogenesis

Molecular immune pathogenesis and diagnosis of COVID-19 (Review by Rob Destefano, MS4)
Hypothesis for potential pathogenesis of SARS-CoV-2 infection - A review of immune changes in patients with viral pneumonia (Review by Kaitlyn Wehrheim, MS2)

Treatment

The feasibility of convalescent plasma therapy in severe COVID- 19 patients: A pilot study (Review by Manvita Tatavarthy, MS2)
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV (Review by Caleb Bailie, MS1)
Tocilizumab treatment in COVID‐19: A single center experience. (Review by Amanda Narkis, MS2)
High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019 (Review by Karina Oelerich, MS2)
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 (Review by Ashley Wehrheim, MS2)

Vaccine Development

An effective CTL peptide vaccine for Ebola Zaire based on survivors’ CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design (Review by Emily Beltran, MS1)
COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics (Review by Ahmad Gill, MS3)

April 25, 2020

New reviews today addressed the following 5 studies:

Public Health

School closure and management practices during coronavirus outbreaks including COVID-19 (Review by Josh Doppelt, MS4)
Covid-19: control measures must be equitable and inclusive (Reviewed by Laura Hurley, MS3)

Epidemiology

Spread of SARS-CoV-2 in the Icelandic population (Review by Gary Wu, MS3)
Epidemiology of 2019 Novel Coronavirus Disease-19 in Gansu Province, China, 2020 (Review by Antonios Skondras, MS2)

Critical Care

High-flow nasal-oxygenation-assisted fiberoptic tracheal intubation in critically ill patients with COVID-19 pneumonia (Review by Shyam Desai, MS4)

April 24, 2020

Biology

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. (Review by Jackie Urban, MS4)

Epidemiology

Comparison of hospitalized patients with acute respiratory distress syndrome caused by COVID-19 and H1N1 (Review by Bryant Yu, MS2)
The reproductive number of COVID-19 is higher compared to SARS coronavirus (Review by Conor Flavin, MS3)
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? (Review by Joseph Dodson, MS1)
First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: A modelling impact assessment (Review by Connon Wakefield, MS3)

Pathogenesis

Pathogenesis of COVID-19 from a cell biology perspective (Review by John Bretzman, MS4)

Diagnosis

Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? (Review by Paul Parker, MS4)

Treatment

Clinical and microbiological effects of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study (Review by Christina Brown, MS2)
Treatment of 5 critically ill patients with COVID-19 with convalescent plasma (Review by Amanda Narkis, MS2)Vaccine development
The COVID-10 vaccine development landscape (Review by Leah Greenfield, MS1)

April 23, 2020

Biology

Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (Review by Beth Hall, MS4)

Epidemiology

Epidemiology and clinical features of coronavirus disease 2019 in children (Review by Alice Burgess, MS2)

Diagnosis

Serum Amyloid A is a biomarker to distinguish the severity and prognosis of coronavirus disease 2019 (COVID-19) (Review by Kelsey Danley, MS4)

Treatment

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial (Review by Joseph deBettencourt, MS3)

Vaccine Development

SARS-CoV-2 and SARS-CoV spike-RBD structure and receptor binding comparison and potential implications on neutralizing antibody vaccine development (Review by John Sweeney, MS3)
Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV ): a systematic review (Review by Leah Greenfield, MS1)