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Nadine Lerret, PhD, MLS(ASCP)CM

Program Director, Medical Laboratory Science
Associate Professor, Department of Medical Laboratory Science, College of Health Sciences
Education

PhD, Immunology and Microbiology, Rush University
BS, Clinical Laboratory Science, University of Wisconsin-Milwaukee

Contact Info:

600 S. Paulina St.
1021 AAC
Chicago, IL 60612
Phone: (312) 942-2780
nadine_lerret@rush.edu
Links:
Biography

Nadine Lerret, PhD, MLS(ASCP)CM, received her doctorate in immunology from Rush, where she analyzed the role that CD8 T cells and dendritic cells played in a humanized mouse model of breast cancer.  She went on to postdoctoral research endeavors at Northwestern University, specifically focusing on whether T cell intrinsic MyD88 signaling regulates the host immune response following kidney transplantation.  While she is classically trained in basic science research, she also is a certified medical laboratory scientist.  This combination drives her research interest in examining the interplay between T cells and dendritic cells in patients with metabolic disease and chronic hyperglycemia.   Lerret’s long term research goals are to be part of an interdisciplinary research team focused on patients with pre-diabetes and methods that can be utilized in order to stop the progression to overt diabetes.  Her primary teaching responsibilities are in the Department of Medical Laboratory Sciences, where she is the clinical chemistry course director.

Publications

Selected Publications

Quick Review Cards for Medical Laboratory Science, 3rd ed.   Valerie Dietz Polansky and Nadine Lerret, 2022, FA Davis, Philadelphia, PA

Owaja C, Roback-Navarro E, Iwai N, Lerret NM.  Hyperglycemia Alters the CD27-CD70 Axis on Human PBMCs.  Clinical Laboratory Science; January 2020.  DOI: https://doi.org/10.29074/ascls.119.002089

Iwai N, Steib C, Marzo A, Lerret NM. The Role of Hyperglycemia in CD4 T Cell Survival and Differentiation.  Clinical Laboratory Science.  October 2018 https://www.semanticscholar.org/paper/The-Role-of-Hyperglycemia-in-CD4-T-Cell-Survival-Iwai-Steib/01a461f9a62c4f655a50e4a1cd3f07ef27a80986

Bryant, J., Lerret, N.M., Wang, J., Kang, H.K., Tasch, J., Zhang, Z. and Luo, X. (2014). Preemptive Donor Apoptotic Cell Infusions Induce IFN-gamma-Producing Myeloid Derived Suppressor Cells for Cardiac Allograft Protection. Journal of Immunology. 192(12), 60692-6101 *co-first author

Lerret, N.M., and Luo, X. (2014). IL-15 expanded CD8+CD122+ cells: When do they suppress? American Journal of Transplantation. 14(1), 7-8. 

Lerret, N.M., and Marzo, A.L. (2013) Adoptive Transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of TBI eradicates breast tumors (Author Review). Oncoimmunology. 2(2),

Lerret, N.M., Houlihan, J.L., Kheradmand, T, Pothoven, K.L., Zhang, Z, and Luo, X. (2012). Donor-specific CD8+Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+Foxp3+ regulatory T cells. American Journal of Transplantation. 12(9):2335-47.

Lerret, N.M., Rogozinska, M, Jaramillo, A, and Marzo, A.L. (2012). Adoptive Transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of TBI eradicates breast tumors. PLoS ONE. 7, 1-5