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Lei Duan, MD

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Lei Duan, MD

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Associate Professor, Department of Anatomy & Cell Biology

Rush Medical College

Associate Professor, Department of Anatomy & Cell Biology

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Address: 1750 W. Harrison St., Suite 1303
Chicago, IL 60612
Phone:
(312) 942-5514
Email:
lei_duan@rush.edu

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MD, Shanghai Jiaotong University Medical School, China
Lei Duan, MD, serves as an Associate Professor in the Department of Anatomy & Cell Biology at Rush University Medical Center. Duan obtained his MD degree from Shanghai Jiaotong University Medical School in China and pursued postdoctoral training at Harvard Medical School, focusing on signal transduction and cancer biology. Over the past 14 years, Duan has dedicated his research efforts to translational cancer research at Rush University Medical Center. His work primarily focuses on understanding therapy resistance in breast and lung cancers, with a particular emphasis on investigating the molecular mechanisms underlying endocrine therapy resistance in estrogen receptor-positive breast cancer.
Complete list of published work on PubMed

Complete list of published work on Scopus

1. Duan L, Perez RE, Chen L, Blatter LA, Maki CG. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. J Mol Cell Biol. 2017 Nov 27. doi: 10.1093/jmcb/mjx051. [Epub ahead of print] PubMed [citation] PMID: 29190376

2. Duan L, Maki CG. The IGF-1R/AKT pathway determines cell fate in response to p53. Transl Cancer Res. 2016 Dec;5(6):664-675. doi: 10.21037/tcr.2016.09.16. PubMed [citation] PMID: 28966916, PMCID: PMC5617345

3. Davaadelger B, Perez RE, Zhou Y, Duan L, Gitelis S, Maki CG. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer Biol Ther. 2017 Nov 2;18(11):895-903. doi:10.1080/15384047.2017.1345397. Epub 2017 Jul 11. PubMed [citation] PMID: 28696156, PMCID: PMC5710671

4. Davaadelger B, Duan L, Perez RE, Gitelis S, Maki CG. Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor. Oncotarget. 2016 May 10;7(19):27511-26. doi: 10.18632/oncotarget.8484. PubMed [citation] PMID: 27050276, PMCID: PMC5053668

5. Perez RE, Shen H, Duan L, Kim RH, Kim T, Park NH, Maki CG. Modeling the Etiology of p53-mutated Cancer Cells. J Biol Chem. 2016 May 6;291(19):10131-47. doi: 10.1074/jbc.M116.724781. Epub 2016 Mar 28. PubMed [citation] PMID: 27022024, PMCID: PMC4858965

6. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed [citation] PMID: 26799652, PMCID: PMC4835977

7. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed [citation] PMID: 26337205, PMCID: PMC4695109

8. Duan L, Perez RE, Hansen M, Gitelis S, Maki CG. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer Biol Ther. 2014;15(12):1600-12. doi: 10.4161/15384047.2014.961876. PubMed [citation] PMID: 25482935, PMCID: PMC4623033

9. Duan L, Danzer B, Levenson VV, Maki CG. Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells. Cancer Lett. 2014 Oct 28;353(2):290-300. doi: 10.1016/j.canlet.2014.07.031. Epub 2014 Jul 25. PubMed [citation] PMID: 25069039, PMCID: PMC4827626

10. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed [citation] PMID: 24936056, PMCID: PMC4118128

11. Ortega-Cava CF, Raja SM, Laiq Z, Bailey TA, Luan H, Mohapatra B, Williams SH, Ericsson AC, Goswami R, Dimri M, Duan L, Band V, Naramura M, Band H. Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer. J Carcinog. 2011;10:29. doi: 10.4103/1477-3163.90443. Epub 2011 Nov 30. PubMed [citation] PMID: 22190871, PMCID: PMC3243085

12. Raja SM, Clubb RJ, Ortega-Cava C, Williams SH, Bailey TA, Duan L, Zhao X, Reddi AL, Nyong AM, Natarajan A, Band V, Band H. Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. Cancer Biol Ther. 2011 Jan 15;11(2):263-76. Epub 2011 Jan 15. PubMed [citation] PMID: 21088503, PMCID: PMC3047084

13. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed [citation] PMID: 21087932, PMCID: PMC3024782

14. Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H. Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem. 2011 Jan 7;286(1):620-33. doi: 10.1074/jbc.M110.188086. Epub 2010 Oct 12. PubMed [citation] PMID: 20940296, PMCID: PMC3013022

15. Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. J Biol Chem. 2010 Jan 8;285(2):1555-68. doi: 10.1074/jbc.M109.057976. Epub 2009 Oct 13. PubMed [citation] PMID: 19826000, PMCID: PMC2801280

16. Zhao X, Lu L, Pokhriyal N, Ma H, Duan L, Lin S, Jafari N, Band H, Band V. Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res. 2009 Jan 15;69(2):483-91. doi:
10.1158/0008-5472.CAN-08-2907. PubMed [citation] PMID: 19147561, PMCID: PMC2792911

17. Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P, Druker BJ, Naramura M, Band V, Band H. Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem. 2007 Oct 5;282(40):29336-47. Epub 2007 Jul 9. PubMed [citation] PMID: 17620338

18. Dimri M, Naramura M, Duan L, Chen J, Ortega-Cava C, Chen G, Goswami R, Fernandes N, Gao Q, Dimri GP, Band V, Band H. Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior. Cancer Res. 2007 May 1;67(9):4164-72. PubMed [citation] PMID: 17483327

19. Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N. A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5413-8. Epub 2007 Mar 19. PubMed [citation] PMID: 17372230, PMCID: PMC1828708

20. Gan H, He X, Duan L, Mirabile-Levens E, Kornfeld H, Remold HG. Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential. J Infect Dis. 2005 Apr 15;191(8):1292-300. Epub 2005 Mar 14. PubMed [citation] PMID: 15776376

21. Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity. 2004 Jul;21(1):7-17. Review. PubMed [citation] PMID: 15345216

22. Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H. Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20;279(34):36132-41. Epub 2004 Jun 18. PubMed [citation] PMID: 15208330

23. Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24. PubMed [citation] PMID: 12881521

24. Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem. 2003 Aug 1;278(31):28950-60. Epub 2003 May 18. PubMed [citation] PMID:
12754251

25. Duan L, Gan H, Golan DE, Remold HG. Critical role of mitochondrial damage in determining outcome of macrophage infection with Mycobacterium tuberculosis. J Immunol. 2002 Nov 1;169(9):5181-7. PubMed [citation] PMID: 12391235

26. Duan L, Gan H, Arm J, Remold HG. Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra. J Immunol. 2001 Jun 15;166(12):7469-76. PubMed [citation] PMID: 11390500
Swim Across America 2023
PI (Duan)
A synthetic lethality approach for NSCLC with co-occurring mutations of KRAS and KEAP1
09/2023-08/2024

Department of Defense W81XWH2210134 (Maki)
Co-investigator (Duan)
Rational targeting of TTK/MPS1 in HER2-negative breast cancer
03/2022-02/2025

NIH NCI R21CA273658 (Maki)
Co-Investigator (Duan)
A synthetic lethal approach for targeting p53 deficient triple negative breast cancer
04/2023-03/2025

NIH NCI 1R01CA200232-01A1 (Maki)
Co-investigator (Duan)
Targeting prolylpeptidases in tamoxifen resistant breast cancer
7/01/2015-5/31/2021

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