Jagarapu J., Kelchtermans J., Rong M., Chen S., Hehre D., Hummler S., Faridi M.H., Gupta V., and Wu S., Leukadherin-1 Attenuates Hyperoxia-induced Lung Injury in Neonatal Rats, Am J Respir Cell Mol Biol. 2015 April 24. [Epub ahead of print]. PMID: 25909334. DOI: 10.1165/rcmb.2014-0422OC. Online link
Lee H.W., Khan S.Q., Faridi M.H., Wei C., Tardi N.J., Altintas M.M., Elshabrawy H.A., Mangos S., Quick K.L., Sever S., Reiser J. and Gupta V., A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules, J Am Soc Nephrol. 2015 April 9, 2015. pii: ASN.2014090859. [Epub ahead of print]. PMID: 25858967. doi: 10.1681/ASN.2014090859. Online link
Khan S.Q., Guo L., Cimbaluk D.J., Elshabrawy H., Faridi M.H., Jolly M., George J.F., Agarwal A. and Gupta V., A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy, Front. Med., 2014 12 Nov. 2014. doi: 10.3389/fmed.2014.00045 Online link
Gupta V. and Reiser J., MicroRNAs: A Macroview Into Focal Segmental Glomerulosclerosis, Am J Kidney Dis. 2015 Feb.; 65(2):206-8. doi:10.1053/j.ajkd.2014.11.003 Online link
Rodriguez-Menocal L., Faridi M.H., Martinez L., Shehadeh L.A., Duque J.C., Wei Y., Mesa A., Pena A., Gupta V., Pham S.M. and Vazquez-Padron R.I., Macrophage-derived IL-18 and Increased Fibrinogen Deposition are Age-related Inflammatory Signatures of Vascular Remodeling, American Journal of Physiology – Heart and Circulatory Physiology, 2014 March 2014, Vol. 306, no. 5, H641-H653. doi:10.1152/ajpheart.00641.2013. Online link
Cascão R., Vidal B., Raquel H., Neves-Costa A., Figueiredo N., Gupta V., Fonseca J.E. and Moita L.F., Potent Anti-Inflammatory and Anti-Proliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis, Mediators of Inflammation, 2014 Jan., Volume 2014 (2014), Article ID 195327. doi:10.1155/2014/195327 Online link
Celik E., Faridi M.H., Kumar V., Deep S., Moy V.T. and Gupta V., Agonist Leukadherin-1 Increases CD11b/CD18 Dependent Adhesion via Membrane Tethers, Biophysical Journal, 2013 Dec., Volume 105, Issue 11, 2517-2527. doi:10.1016/j.bpj.2013.10.020. Online link
Weston W., Gupta V., Adkins R., Jurecic R., New Therapeutic Approaches for Protecting Hematopoietic Stem Cells in Aplastic Anemia, Immunol Res, 2013 Dec.; 57(1-3):34-43. doi:10.1007/s12026-013-8449-0. Online link
Figueiredo N., Chora A., Raquel H., Pejanovic N., Pereira P., Hartleben B., Neves-Costa A., Moita C., Pedroso D., Pinto A., Marques S., Faridi H., Costa P., Gozzelino R., Zhao J.L., Soares M.P., Gama-Carvalho M., Martinez J., Zhang Q., Döring G., Grompe M., Simas J.P., Huber T.B., Baltimore D., Gupta V., Green D.R., Farreira J.A., Moita L.F., Anthracyclins Induce Autophagy-mediated Protection From Severe Sepsis, Immunity, 2013 Nov. 14; 39(5):874-84. doi:10.1016/j.immuni.2013.08.039. Online link
Yu C.C., Fornoni A., Weins A., Hakroush S., Maiguel D., Sageshima J., Chen L., Ciancio G., Faridi M.H., Behr D., Campbell K.N., Chang J.M., Chen H.C., Oh J., Faul C., Arnaout MA, Fiorina P, Gupta V, Greka A, Burke G, Mundel P, Abatacept in B7-1 Positive Proteinuric Kidney Disease, New England Journal of Medicine, 2013 Nov. 8. doi:10.1056/NEJMoa1304572. Online link
Faridi M.H., Altintas M.M., Gomez C., Duque J.C., Vazquez-Padron R.I., Gupta V., Small Molecule Agonists of Integrin CD11b/CD18 Do Not Induce Global Conformational Changes And Are Significantly Better Than Activating Antibodies in Reducing Vascular Injury, Biochimica et Biophysica Acta, 2013 June; 1830(6):3696-710. doi: 10.1016/j.bbagen.2013.02.018. Online link
Reed R.H., Jain M., Lee K., Kandimalla E.R., Faridi M.H., Buyon J.P., Gupta V., Clancy R.M., Complement Receptor 3 Influences Toll-like Receptor 7/8 Dependent Inflammation: Implications for Autoimmune Diseases Characterized by Antibody Reactivity to Ribonucleoproteins, J Biol Chem, 2013. Mar. 29; 288(13):9077-83. doi: 10.1074/jbc.M112.403303. Online link
Cascão R., Vidal B., Raquel H., Neves-Costa A., Figueiredo N., Gupta V., Fonseca J.E., Moita L.F., Effective Treatment of Rat Adjuvant-induced Arthritis by Celastrol, Autoimmun Rev, 2012. Oct.; 11(12):856-62. doi: 10.1016/j.autrev.2012.02.022. Epub 2012 Mar 3.
Maiguel D., Faridi M.H., Wei C., Kuwano Y., Balla K.M., Hernandez D., Barth C.J., Lugo G., Donnelly M., Nayer A., Moita L.F., Schürer S., Traver D., Ruiz P., Vazquez-Padron R.I., Ley K., Reiser J., Gupta V., Small Molecule-mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease, Science Signaling, 2011 Sept. 6; 4(189):ra57. PMID: 21900205 Article link This work was featured in a highlight in Nature Reviews in Immunology, 11, 638 (October 2011) and in a highlight in Acta Pharmacologica Sinica (2011) 32: 1309–1310.
Wei C., El Hindi S., Li J., Fornoni A., Goes N., Sageshima J., Maiguel D., Karumanchi S.A., Yap H.K., Saleem M., Zhang Q., Nikolic B., Chaudhuri A., Daftarian P., Salido E., Torres A., Salifu M., Sarwal M.M., Schaefer F., Morath C., Schwenger V., Zeier M., Gupta V., Roth D., Rastaldi M.P., Burke G., Ruiz P., Reiser J., Circulating Urokinase Receptor as a Cause of Focal Segmental Glomerulosclerosis. Nature Medicine, 2011 July 31; 17(8):952-60. doi: 10.1038/nm.2411. PMID: 21804539 Online link This work was featured as a cover article and in a highlight in the same issue of Nature Medicine.
Faridi M.H., Maiguel D., Brown B.T., Suyama E., Barth C.J., Hedrick M., Vasile S., Sergienko E., Schürer S., Gupta V., High-throughput Screening Based Identification of Small Molecule Antagonists of Integrin CD11b/CD18 Ligand Binding, Biochem Biophys Res Commun, 2010, Mar. 26; 394(1):194-9. Epub 2010 Feb 25. PMID: 20188705.
File link
Reiser J., Gupta V., Kistler A.D., Toward the Development of Podocyte-specific Drugs, Kidney International 2010 Apr.; 77(8):662-8. Epub 2010 Feb. 3. PMID: 20130528. Online link
Faridi M.H., Maiguel D., Barth C.J., Stoub D., Day R., Schürer S., Gupta V., Identification of Novel Agonists of the Integrin CD11b/CD18, Bioorg Med Chem Lett, 2009 Dec. 15; 19(24):6902. NIHMS154324. File link
Qureshi A.H., Chaoji V., Maiguel D., Faridi M.H., Barth C.J., Salem S.M., Singhal M., Stoub D., Krastins B., Ogihara M., Zaki M.J., Gupta V., Proteomic and Phospho-proteomic Profile of Human Platelets in Basal, Resting State: Insights Into Integrin Signaling, PLoS One, 2009 Oct. 27; 4(1):e7627. File link
Banerjee A., Sergienko E., Vasile S., Gupta V., Vuori K. and Wipf P., Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras, Organic Letters, 2009 Jan. 1; 11(1):65.
Gupta V., Alonso J.L., Sugimori T., Issafi M., Xiong J.P. and Arnaout M.A., Role of the Beta-subunit Arginine/Lysine Finger in Integrin Heterodimer Formation and Function, Journal of Immunology, 2008 Mar. 1; 180(5):3613. File link
Wei C., Möller C.C., Altintas M.M., Li J., Schwarz K., Zacchigna S., Xie L., Henger A., Schmid H., Rastaldi M.P., Cowan P., Kretzler M., Parrilla R., Bendayan M., Gupta V., Nikolic B., Kalluri R., Carmeliet P., Mundel P. and Reiser J., Modification of Kidney Barrier Function by the Urokinase Receptor, Nature Medicine, 2008 Jan.; 14(1):55-63. Epub 2007 Dec. 16. File link
Park J.Y., Arnaout M.A. and Gupta V., A Simple, No-wash Cell-adhesion Based High Throughput Assay for the Discovery of Small Molecule Regulators of the Integrin CD11b/CD18, Journal of Biomolecular Screening, 2007 Apr.; 12 (3):406-17. File link
Gupta V., Gylling A., Alonso, J.L., Sugimori T., Ianakiev, P., Xiong J.P. and Arnaout M.A.,The β-tail Domain (βTD) Regulates Physiologic Ligand Binding to Integrin CD11b/CD18, Blood, 2007 Apr. 15;109(8):3513-20. Epub 2006 Dec. 14 (DOI 10.1182/blood-2005-11-056689). File link This work was featured in a Highlight in the same issue of Blood.
Gupta* V., Cherkassky A., Chatis P., Joseph R., Johnson A. J., Erickson T. and Dimeo J., Directly Labeled mRNA Produces Highly Precise and Unbiased Differential Gene Expression Data, Nucleic Acids Research, 2003, 31, e13. File link
Werner M.H., Nagata T., Gupta V., Goger M., Chait B.T., Sâli A., Kim W.Y., Shigesada K., Ito Y., Molecular Insights Into The Origin of the Acute Human Leukemias Revealed From the Three-dimensional Structure and Sub-cellular Localization of AML1, Clinical Cancer Res, 1999, 5, 3780S.
Werner M. H., Gupta V., Lambert L.J. and Nagata T., Uniform 13C/15N-labeling of DNA by Tandem Repeat Amplification, Methods in Enzymology, 2001, 338, 283-304. File link
Nagata* T., Gupta* V., Sorce D., Kim W.Y., Sâli A., Chait B.T., Shigesada K., Ito Y. and Werner M. H., Immunoglobulin-motif DNA Recognition and Heterodimerization for the PEBP2/CBF Runt-domain, Nature Structural Biology, 1999, 615-619. File link
Goger* M., Gupta* V., Kim W.Y., Shigesada K., Ito Y. and Werner M.H., Molecular Insights Into PEBP2/CBF-SMMHC Associated Acute Leukemias Revealed From The Three-dimensional Structure of PEBP2/CBF Beta, Nature Structural Biology, 1999, 620-623. File link
Gupta V. and Kool E. T. A Novel Self-Cleaving DNA Nucleoside, Chemical Communications, 1997, 1425-26. File link
Jayaram B., Aneja N., Rajsekaran E., Arora V., Das A., Ranganathan V. and Gupta V., Modeling DNA in Aqueous Solution, Journal of Scientific and Industrial Research, 1994, 53 (2), 88-105.
Other publications
Cheng, Q., Ogihara, M., and Gupta, V., Learning Condition-dependent Dynamical PPI Networks from Conflict-sensitive Phosphorylation Dynamics, in Proceedings of the IEEE Conference on Biomedicine and Computational Biology (IEEE-BIBM), 2011. B459. Online link
Jain, Manish; Amato, Michael; Buyon, Jill P.; Gupta V.; Clancy, Robert M.; A Novel CR3 Agonist Attenuates Pro-Inflammatory Signaling in Subjects with Common and Variant ITGAM Polymorphism, rs1143679. Arthritis Rheum 2011; 63 Suppl. 10 :1675.
Cascão R., Vidal B., Raquel H., Neves-Costa A., Figueiredo N., Gupta V., Fonseca J.E., Moita L.F.; Drugs That Simultaneously Down-regulate IL-1b and TNF Secretion Significantly Reduce Inflammation in a Rat Model of Antigen-induced Arthritis, Journal of Translational Medicine 2011, 9(Suppl 2):P21.
Cheng Q., Gupta V., and Ogihara M.; Inferring Conflicting Phosphorylation Dynamics, in Proceedings of the ACM Conference on Computational Biology and Biomedicine (ACM-BCB), 2011.
Dony Maiguel; Mohd. Hafeez Faridi; Roberto Vazquez-Padron; Vineet Gupta; Novel Small Molecule Agonists of Integrin Cd11b/cd18 Reduce Leukocyte Migration and Post Injury Neointimal Hyperplasia, Circulation 2010; 122: A16106.
Gupta V., Parthasarathsy S. and Zaki M.J., Arithmetic and Logic Operations with DNA, Proceedings of the 3rd DIMACS Workshop on DNA Based Computers 1997, 212-220. File link
Gupta V.; Studies Aimed at Controlled Chemical Cleavage of DNA. Thesis, 1997 University Of Rochester, 1997.
Gupta V.; Computer Modeling and Theoretical Studies of Drug-DNA Interactions. Thesis, 1992 Indian Institute of Technology, Delhi; 1992.
Published patents and patent applications
Gupta V. and Werner M.H., Methods for Preparing Polynucleotide Sequences and Uses Thereof, Patent number US6194179, 2001. Download file.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent number US6905816. Download file.
Chui B., Elghanian R.E., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis, Patent Number US6986992. Download file.
Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Number US7223538.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7566533.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7622250.
Jacobs A.A., Gupta V. and Nikolic B., Devices and methods for diagnosis of susceptibility to diseases and disorders, Patent Number US7998679.
Gupta V. and Arnaout M.A., Compounds for Modulating Integrin CD11b/CD18. Patent Number US8268816.
Gupta V. and Werner M.H., Methods for Preparing Quantities of Preselected Polynucleotide Sequences and Uses Thereof, WO/2001/006017. Download file.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2002/0095073. Download file.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, WO/2002/042775. Download file.
Luehrsen K.R., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis. WO/2002/083839. Download file.
Brush C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Pending US2003/0119005. Download file.
Jacobs A.A., Gupta V. and Nikolic B., Methods and Devices for Detecting Hydrocarbons and Petroleum Products, WO/2003/012390. Download file.
Brush C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids and Uses Thereof, WO/2003/052115. Download file.
Xia J. and Gupta V. et al., Compositions and Methods for Rolling Circle Amplification, Patent Pending US2004/0014078. Download file.
Jacobs A.A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2005/0191694. Download file.
Gupta V., Nikolic B. and Gupta V., Water-based Personal Moisturizers and Lubricants, in Particular Vaginal Lubricants, and Uses Thereof, Patent Pending US2006/0204557. Download file.
Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2006/0240453. Download file.
Gupta V. and Arnaout M.A.;Compounds for Modulating Integrin CD11b/CD18. Patent Number US8268816.
Gupta V.; Compounds and Methods for Regulating Integrins. Patent Pending US20120010255.
Gupta V. and Arnaout M.A. Compounds for Modulating Integrin CD11b/CD18. Patent Pending US20130045967.
