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Chen
Di
MD, PhD
The John W. and Helen Watzek Professor of Biochemistry
Professor Chairman of Department of Biochemistry
Biochemistry
Graduate College, Rush University
Cohn Research Building
1735 West Harrison Street, Suite 508
Chicago, IL 60612-3823
Cohn Research Building
1735 West Harrison Street, Suite 536
Chicago, IL 60612-3823
(312) 942-2711
(312) 942-3053
di_chen@rush.edu
MD, Tianjin University, China, 1982
PhD, University of Louisville, US, 1992
Behavior and Behavior Mechanisms, Biological Phenomena Cell Phenomena and Immunity
Flow Cytometry, PCR, Real-time PCR, si RNA, Western Northern Southern Blotting





The current research in Chen laboratory mainly focuses on the elucidation of molecular mechanisms associated with degenerative and genetic bone diseases. Particularly, we are interested in pathophysiological roles of canonical Wnt/β-catenin, TGF-β, and BMP signaling in bone and cartilage cells. We are also interested in the role of specific microRNAs in regulation of bone-specific transcription factor Runx2 and SUMO- regulation mechanism of specific cell cycle protein cyclin D1 in cancer cells. We hope that our studies will ultimately lead to the novel therapeutic intervention for various human diseases.
1. Skeletal development and remodeling
2. Molecular mechanisms of degenerative bone diseases (such as osteoarthritis and intervertebral disc degeneration)
3. Genetic bone diseases
4. Canonical Wnt, BMP and TGF-β signaling in chondrocytes and in osteoblasts
5. Protein post-transcriptional regulation (such as ubiquitination, SUMOylation and micro-RNA regulation).
 

Our lab uses extensively the molecular biology and molecular genetic techniques.
1) We create a variety of genetic mouse models, including transgenic mice, knockout mice and conditional or inducible knockout mice, to investigate orthopaedic diseases and metabolic bone diseases.
2) We also perform in vitro signaling and biochemical studies using techniques, such as cell culture, transfection, molecular cloning, PCR, Western blotting, immunoprecipitation, flow cytometry.

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