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Xiao
Guozhi
MD, PhD
Associate Professor
Director of Research, Department of Biochemistry
Biochemistry
Rush Medical College
Cohn Research Building
1735 West Harrison Street
Suite 518
Chicago, IL 60612-3823
(312) 942-4879
(312) 942-3053
guozhi_xiao@rush.edu
1979-1984, MD, Nanchang University School of Medicine, China
1985-1988, MS, Peking(Beijing) University Health Science Center, China
1991-1994, PhD, Peking(Beijing) University Health Science Center, China
Animal surgery/Modeling, Cytokine Assessment, ELISA Development, Flow Cytometry, Gene Chip Technologies, Gene Transfection, Imaging Techonology, Immunohisto-/immunocytochemistry, Micro Computed Tomography (Microct), PCR, Real-time PCR, si RNA, Spectrophotometry, Transgenic Animal Technology/Microinjection, Ultra centrifugation techniques, Western Northern Southern Blotting

My research focuses in two main areas – how osteoblast (the bone-forming cell) gene expression and differentiation and bone formation are regulated by PTH and other factors, and, more recently, how osteoclast (the bone-resorbing cell) differentiation and bone resorption are modulated at the molecular level under physiological and pathological conditions.

  • The mechanism by which activating transcription factor 4 (ATF4) mediates the anabolic actions of PTH in bone.
  • The mechanism whereby ATF4 modulates osteoclast differentiation and bone resorption using in vitro and animal mode systems.
  • The mechanism by which multiple myeloma and breast cancer metastases impact osteoblast and osteoclast activity and bone function.
  • The mechanisms that modulate bone angiogenesis during skeletal development and under hypoxic conditions.
  • The role of migfilin and other related factors in regulation of bone remodeling.

By working on these projects, I have also maintained a focus on medical issues involving bone - osteoporosis and metastatic osteolytic lesions and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.

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