|Last Name: ||Xiao|
|First Name: ||Guozhi|
|M. I.: |
|Degree & Certifications: ||MD, PhD|
|Endowed Professorship: |
|Rank & Title: ||Associate Professor |
Director of Research, Department of Biochemistry
|College: ||Rush Medical College|
|Office Location: |
|Laboratory Location: ||Cohn Research Building|
1735 West Harrison Street
Chicago, IL 60612-3823
|Phone: ||(312) 942-4879|
|Fax: ||(312) 942-3053|
|Education: ||1979-1984, MD, Nanchang University School of Medicine, China |
1985-1988, MS, Peking(Beijing) University Health Science Center, China
1991-1994, PhD, Peking(Beijing) University Health Science Center, China
|Research Areas: |
|Laboratory Techniques: ||Animal surgery/Modeling, Cytokine Assessment, ELISA Development, Flow Cytometry, Gene Chip Technologies, Gene Transfection, Imaging Techonology, Immunohisto-/immunocytochemistry, Micro Computed Tomography (Microct), PCR, Real-time PCR, si RNA, Spectrophotometry, Transgenic Animal Technology/Microinjection, Ultra centrifugation techniques, Western Northern Southern Blotting|
|Faculty/Staff Description: ||
My research focuses in two main areas – how osteoblast (the bone-forming cell) gene expression and differentiation and bone formation are regulated by PTH and other factors, and, more recently, how osteoclast (the bone-resorbing cell) differentiation and bone resorption are modulated at the molecular level under physiological and pathological conditions.
- The mechanism by which activating transcription factor 4 (ATF4) mediates the anabolic actions of PTH in bone.
- The mechanism whereby ATF4 modulates osteoclast differentiation and bone resorption using in vitro and animal mode systems.
- The mechanism by which multiple myeloma and breast cancer metastases impact osteoblast and osteoclast activity and bone function.
- The mechanisms that modulate bone angiogenesis during skeletal development and under hypoxic conditions.
- The role of migfilin and other related factors in regulation of bone remodeling.
By working on these projects, I have also maintained a focus on medical issues involving bone - osteoporosis and metastatic osteolytic lesions and fracture healing. Information obtained from these studies will enhance our understanding of these pathological processes.