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Assistant Professor
Neurological Sciences
Graduate College
1735 W. Harrison Cohn Research Building Room 314 Chicago,IL 60612
1735 W. Harrison Cohn Research Building Lab 353 Chicago,IL 60612
(312) 563-3569
(312) 563-3571
Davidson College, Davidson, NC, AB
Emory University, Atlanta, GA, PhD
Biological Sciences, Chemical and Pharmacologic Phenomena, Genetic Processes, Mental Disorders, Nervous System Diseases, Pathological Conditions Signs and Symptoms
Chromatography, Elisa/Plate reading, Gene Chip Technologies, Immunohisto-/immunocytochemistry, Laser Capture, Microscopy (Electron Transmission Fluorescence Confocal), PCR, Proteomics, Real-time PCR, si RNA, Spectrophotometry, Ultra centrifugation techniques, Western Northern Southern Blotting
The goal of my research is to understand the pathogenic mechanisms of Alzheimer's disease (AD) and its putative preclinical stage, mild cognitive impairment (MCI). Specific topics of interest include gene regulation within vulnerable cholinergic basal forebrain (CBF) and noradrenergic locus coeruleus (LC) projection neurons in MCI and AD, the functional consequences of CBF and LC neurodegeneration during disease progression, the characterization of novel gene products dysregulated within the hippocampus and neocortex in MCI and AD, and the discovery of potential cerebrospinal fluid biomarkers for MCI. These studies are addressed by combining state-of-the-art functional genomic approaches with autopsied tissue from participants in Rush's Religious Orders Study who died with a clinical diagnosis of no cognitive impairment, MCI, or AD. This allows us the unique opportunity to correlate our findings with the wealth of antemortem clinical and cognitive data available for these subjects. Integrating a rational understanding of disease mechanisms with current knowledge of clinical disease and human neuropathology offers the greatest hope for advancing translational research to improve the treatment of this complex neurodegenerative disease.
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