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Nicholson
Daniel
A.
PhD
Assistant Professor
Neurological Sciences
Rush Medical College
1750 W. Harrison St.
Jelke Building
Suite 1474
Chicago, IL 60612
1750 W. Harrison St.
Jelke Building
Suite 1474
Chicago, IL 60612
(312) 942-5418
(312) 942-2380
dan_nicholson@rush.edu
PhD, University of Iowa

BS, University of Illinois

Nervous System Diseases
Immunohisto-/immunocytochemistry, Microscopy (Electron Transmission Fluorescence Confocal), Patch Clamp/Individual Channel Recording

My lab's principal focus is on the synaptopathology of aging and age-related dementia (e.g., Alzheimer's disease). Our approach combines conventional and immunogold serial section electron microscopy with whole-cell patch-clamp physiology, and we are currently focusing on the degradation of hippocampal synapses in aged cognitively impaired rats and transgenic mice harboring Alzheimer's disease-related mutations. Our techniques allow us to identify patterns of synaptic or dendritic disassembly with electron microscopy, and then determine the functional consequences of this disassembly on synaptic transmission and plasticity using whole-cell patch-clamp recordings.

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