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Wyatt
James
K.
PhD, DABSM, CBSM
Associate Professor

Director, Sleep Disorders Service and Research Center
Behavioral Sciences
Rush Medical College
Sleep Disorders and Research Center
710 S. Paulina St., Suite 600
Chicago, IL 60612
(312) 942-5440
(312) 942-8961
jwyatt@rush.edu
PhD, University of Arizona, 1995

MA, University of Arizona, 1992

AB, Brown University, 1989
Behavior and Behavior Mechanisms, Mental Disorders, Physiological Processes, Psychological Phenomena and Processes
Actigraphy, Circadian Phase Assessments, Polysomnography
Additional Training
Internship in Behavioral Medicine, Brown University School of Medicine, 1995

Fellowship in Sleep and Circadian Medicine, Harvard Medical School & Brigham and Women's Hospital, 1998

Research Interests
My major research interests include the following: pathophysiology and treatment of circadian rhythm sleep disorders; modulation of sleep and neurobehavioral functions by circadian and sleep homeostatic factors; sleep disorders medicine, particularly pathophysiology and treatment of insomnia; and qualitative and quantitative analysis of the human sleep and waking EEG.

More specifically, my primary area of research is the pathophysiology and treatment of the six circadian rhythm sleep disorders. Specifically, I am examining delayed sleep phase syndrome in an attempt to investigate the contributions of biological, psychological and social factors in the pathogenesis of this widespread yet poorly understood sleep disorder. In addition to learning about this disorder, these investigations shed light on normal functioning and interactions between the intrinsic circadian timekeeping system and sleep homeostasis.

A related research interest concerns the modulation of neurobehavioral functions and sleep by sleep/wake homeostatic and circadian factors. By neurobehavioral functions, I refer to the collection of psychophysiological, behavioral, subjective and cognitive measures that can be tested as they convergently and divergently provide qualitative and quantitative information about wakefulness. The various psychophysiological measures include spectral analysis of the waking and sleep EEG, visual standardized scoring of the sleep EEG, and visual and auditory event-related potential recordings. The behavioral measures consist of reaction time and psychomotor tracking. Subjective measures include participant-ratings of sleepiness and alertness, mood and performance efficacy. Cognitive measures include simple and complex reaction time, short-term and long-term memory, explicit and implicit memory, and several measures of cognitive throughput. It is noteworthy that the majority of standard neuropsychological instruments are not applicable for use in sleep and circadian protocols, as these measures are not valid for multiple uses over relatively short time frames. Therefore, the challenge is to develop and implement repeatable, valid, reliable short-duration tasks that can be administered via computer to participants in these studies.

In my past research in Boston, I expanded upon the findings of Dr. Derk-Jan Dijk and Dr. Charles Czeisler, who found evidence for a nonadditive interaction between the circadian and sleep/wake systems in the modulation of sleep, subjective alertness, and cognitive throughput. In particular, I tested a wider variety of neurobehavioral measures (as detailed above), as well as expanded the analysis of various metrics from these measures in order to find functions that were modulated by both, only one, or neither of these systems. I also directed two placebo-controlled studies examining pharmacologic countermeasures (melatonin and caffeine) to alleviate sleep disruption and/or neurobehavioral deficits encountered during suboptimal sleep/wake schedules. From these studies, it was possible not only to learn about the various modulatory processes detailed above, but also about the basic neurobehavioral functions themselves.

My other research interests include the putative role of alterations in memory function in the etiology and maintenance of psychophysiological and sleep-state misperception insomnia, the possible use of pharmacologic countermeasures to the neurobehavioral/circadian/sleep disruption associated with insomnia, jet lag, and rotating shift work, and cognitive and behavioral factors associated with the development and maintenance of insomnia.

Society Memberships
American Academy of Sleep Medicine
Sleep Research Society
Illinois Sleep Society
American Psychological Association - General and Division 38
Society for Biological Rhythms

Editorial Board Membership
Sleep

Past and Current Grant Funding
NHLBI
NIMH
NIA
NASA
USAFOSR
Industry

Past ad hoc Grant Reviewer
SBIR
NASA
NSBRI
NIAAA
NIMH

Selected Publications
Wyatt JK, Bootzin RR, Anthony J, Bazant S. (1994). Sleep onset is associated with retrograde and anterograde amnesia. Sleep, 17, 502-511.

Richardson GS, Wyatt JK, Sullivan JP, Orav EJ, Ward AE, Wolf MA, Czeisler CA. (1996). Objective assessment of sleep and alertness in medical house-staff and the impact of protected time for sleep. Sleep, 19, 718-726.

Jewett ME, Wyatt JK, Ritz-De Cecco A, Khalsa SB, Dijk D-J, Czeisler CA. (1999). Time course of sleep inertia dissipation in human performance and alertness. Journal of Sleep Research, 8, 1-8.

Cajochen C, Khalsa SBS, Wyatt JK, Czeisler CA, Dijk D-J. (1999). EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss. American Journal of Physiology: Regulative, Integrative and Comparative Physiology, 277, R640-R649.

Wyatt JK, Ritz-DeCecco A, Czeisler CA, Dijk D-J. (1999). Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. American Journal of Physiology: Regulative, Integrative and Comparative Physiology, 277, R1152-R1163.

Dijk D-J, Neri DF, Wyatt JK, Ronda JM, Riel E, Ritz-De Cecco A, Hughes RJ, Elliot AR, Prisk GK, West JB, Czeisler CA. (2001). Sleep, performance, circadian rhythms and light-dark cycles during space shuttle missions. American Journal of Physiology: Regulative, Integrative and Comparative Physiology, 281, R1647-R1664.

Elliot AR, Shea SA, Dijk D-J, Wyatt JK, Riel E, Neri DF, Czeisler CA, West JB, Prisk GK. (2001). Microgravity reduces sleep disordered breathing in humans. American Journal of Respiratory and Critical Care Medicine, 164, 478-485.

Cajochen C, Wyatt JK, Czeisler CA, Dijk D-J. (2002). Separation of circadian and wake-dependent modulation of EEG activation during wakefulness. Neuroscience, 114, 1047-1060.

Stepanski EJ, Wyatt JK. (2003). Use of sleep hygiene in the treatment of insomnia. Sleep Medicine Reviews, 7, 215-225.

Wyatt JK. (2004). Delayed sleep phase syndrome: pathophysiology and treatment options. Sleep, 27, 1195-1203.

Wyatt JK, Cajochen C, Ritz-De Cecco A, Czeisler CA, Dijk D-J. (2004). Low-dose, repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. Sleep, 27, 374-381.

Wyatt JK, Dijk D-J, Ritz-De Cecco A, Ronda JM, Czeisler CA. (2006). Sleep facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep, 29, 609-618.

Wyatt JK, Stepanski EJ, Kirkby J. (2006). Circadian phase in delayed sleep phase syndrome: predictors and temporal stability across multiple assessments. Sleep, 29, 1075-1080.
 
Wyatt JK.  (2007). Circadian rhythm sleep disorders in children and adolescents.  In OG Jenni & MA Carskadon (Eds.), Sleep Medicine Clinics 2, 387-396.
 
Wyatt JK, Crisostomo, MI (2008). Insomnias.  In H Smith, C Comella, & B Hoegl (Eds.), Sleep Medicine. Cambridge University Press, 97-112.
 
Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk D-J, Czeisler CA, Klerman EB. (2010). Uncovering residual effects of chronic sleep loss on human performance.  Science Translational Medicine, 2, 14ra3. PMID: 20371466; PMCID: PMC2892834
 
Silva EJ, Wang W, Ronda JM, Wyatt JK, Duffy JF. (2010). Circadian and wake-dependent influences on subjective sleepiness, cognitive throughput and reaction time performance in older and young adults.  Sleep, 33, 481-490. PMID: 20394317; PMCID: PMC2849787
 
Duffy JF, Cain SW, Chang AM, Phillips AJK, Munch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP, Czeisler CA.  (2011). Sex difference in the near-24-hour intrinsic period of the human circadian timing system.  Proceedings of the National Academy of Sciences. (Early edition online: May 2, 2011).  PMID: 21536890; PMCID: PMC3176605.
 
Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuckak KM, Carney CE, Chiang A, Crisostomo IC, Lineberger MD, Means MK, Radke RA, Wohlgemuth WK, Krystal AD.  (2011 [online first]). Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses: results of a multi-method/multi-trait analysis.  Archives of General Psychiatry. PMID: 21646568.
 
Park M, Shah RC, Fogg LF, Wyatt JK. (2011). Daytime sleepiness in mild Alzheimer’s disease with and without parkinsonian features.  Sleep Medicine, 12, 397-402. PMID: 21388877
 
Sanchez-Ortuno MM, Carney CE, Edinger JD, Wyatt JK, Harris A. (2011). Moving beyond average values: assessing the night-to-night instability of sleep and arousal in DSM-IV-TR insomnia subtypes.  Sleep, 34, 531-539.  PMID: 21461332, PMCID: PMC3065264.
 
Sanchez-Ortuno MM, Edinger JD, Wyatt JK. (2011).  Daytime symptom patterns in insomnia sufferers: is there evidence for subtyping insomnia?  Journal of Sleep Research, 20, 425-433. PMID: 21205038; PMCID: PMC3135706.
 
Wyatt JK (2011).  Circadian rhythm sleep disorders.  In J. Owens & J.A. Mindell (Eds.), Pediatric Clinics of North America, Sleep in Children & Adolescents.  Elsevier, 621-635.  PMID: 21600345
 
Wyatt JK, Cvengros, JA (2011).  Delayed and advanced sleep phase disorders.  In TJ Barkoukis, JK Matheson, R Ferber, & K Doghramji (Eds.), Therapy in Sleep Medicine.  Elsevier, 402-410.
 
Park M, Hood MC, Shah RC, Fogg LF, Wyatt JK (2012 – Epub ahead of print) Sleepiness, parkinsonian features, and sustained attention in mild Alzheimer’s disease.  Age and Ageing.  PMID: 22743151
 
Wright JP Jr, Bogan RK, Wyatt JK (2012 – ePub ahead of print).  Shift work and the assessment and management of shift work disorder (SWD).  Sleep Medicine Reviews.  PMID:22560640.
 
Wyatt JK, Cvengros JA, Ong JC (2012).  Clinical assessment of sleep disorders.  In CM Morin & C Espie (Eds.), The Oxford Handbook of Sleep and Sleep Disorders.  New York: Oxford University Press, 383-404.
 
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