Research Interests

Human Circadian Rhythms (especially effects of bright light and melatonin),Shift Work, Jet Lag.


Grants

Principal Investigator

1984 - 1986 Human Circadian Rhythms During a Modified Sleep-Wake Schedule, Rush University Committee on Research; $14,252.

1986 - 1989 Applications of Non-24-Hour Sleep-wake Schedules, NIH, NINDS, R23 NS23421, $98,589 direct costs.

1989 - 1999 Shifting Human Circadian Rhythms with Bright Light, NIH, NINDS, R01 NS23421, about $150,000 direct costs/yr.

1987 - 1997 Mechanisms of Antidepressant Effects of Bright Light (bright light treatment of winter depression), NIH, NIMH, R01 MH42768, about $130,000 direct costs/yr.

1995 - 1996 Shifting Human Circadian Rhythms with Exogenous Melatonin, Rush University Committee on Research, $9,580.

1997 - 2001 Melatonin, Human Circadian Rhythms and Sleep, NIH, NINDS, R01 NS35695, about $150,000 direct costs/yr.

1999 - 2008 Practical Circadian Interventions for Night Shift Work, CDC, NIOSH, R01 OH003954, $250,00 direct costs/yr.

2000 - 2005 Reducing Jet-Lag with Practical Circadian Treatments, NIH, NINR, R01 NR07677, $200,000 direct costs/yr.

2003 - 2007 Effects of Short and Long Nights on the Circadian Clock, NIH, NHLBI, R01 HL072408, $250,000 direct costs/yr.

2006 - 2011 Blue Light and Melatonin for Circadian Rhythm Disorders and Jet Lag, NIH, NINR, R01 NR007677, $225,000 direct costs/yr.

2007 - 2011 Phase Response Curves for Home Remedies to Treat Circadian Misalignment, NIH, NHLBI, R01 HL086934, $250,000 direct costs/yr

 

2012 - 2017 Racial Differences in Human Circadian Rhythms NIH, NINR, R01 NR007677, Total Cost = $2,705,706

 

 

Co-Investigator

2008 - 2013 Sleep Length and Circadian Regulation in Humans, NIH, NHLBI, R01 HL083971, $250,000 direct costs/yr. Helen Burgess, PI.

 

2011 - 2014 Circadian Phase Assessments at Home: Validity and Normative Data  NIH, NCCAM, R01 HL105385, Total Cost = $1,139,850. Helen Burgess, P.I.

2012 - 2017 Adolescent Sleep Delay: Circadian Regulation and Phase Shifting with Light NIH, NHLBI, R01 HL105395, Total Cost = 2,059,437. Stephanie Crowley, P.I.
 

Selected Publications

Crowley, SJ, Lee, C, Tseng, CY, Fogg, LF & Eastman, CI. Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. J. Biol. Rhythms, 18: 513-523, 2003.

Burgess, HJ & Eastman, CI. Short nights attenuate light-induced circadian phase advances in humans. J. Clin Endocrinol. Metab., 90: 4437-4440, 2005.

Revell, VL & Eastman, CI. How to trick Mother Nature into letting you fly around or stay up all night. J. Biol. Rhythms, 20: 353-365, 2005.

Revell, VR, Burgess, HJ, Gazda, CJ, Smith, MR, Fogg, LF & Eastman, CI. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J. Clin. Endocrinol. Metab., 91: 54-59, 2006.

Burgess, HJ, Revell, VL, Eastman, CI, A three pulse phase response curve to three milligrams of melatonin in humans. J. Physiol. 586.2: 639-647, 2008.

Burgess, HJ & Eastman, CI. Human tau in an ultradian light-dark cycle. J. Biol. Rhythms, 23 (4): 374-376, 2008.

Eastman, CI & Burgess, HJ. How to travel the world without jet lag. Sleep Medicine Clinics, 4: 241-255, 2009.

Smith, MR, Fogg, LF. & Eastman, CI. A compromise circadian phase position for permanent night work improves mood, fatigue, and performance. Sleep, 32(11): 1481-1489, 2009.

Smith, MR, Burgess, HJ, Fogg, LF & Eastman, CI. Racial differences in the human endogenous circadian period. PLoS ONE 4(6): e6014, 2009. doi:10.1371/journal.pone.0006014, 2009.

Burgess, HJ, Revell, VL, Molina, TA & Eastman CI. Human phase response curves to three days of daily melatonin : 0.5 mg versus 3.0 mg. J. Clin. Endocrinol. Metab, 95(7):3325-3331, 2010.

Eastman, CI. How to get a bigger dose of bright light: A Commentary on Dewan et al. Light-induced changes of the circadian clock of humans: it is more effective to increase duration than light intensity. Sleep, 34 (5): 559-560, 2011. PMID:21532946, PMCID:PMC3079932

Revell, VL & Eastman, CI. Jet lag and its prevention, Chapter 30, pages 390-401, in Therapy in Sleep Medicine, Editors: Barkoukis, T.J., Matheson, J.K., Ferber, R. & Doghramji, K., Elsevier, 2012.

Eastman, CI, Molina, TA, Dziepak, ME & Smith, MR. Blacks (African Americans) have a shorter free-running circadian period than Whites (Caucasian Americans). Chronobiol. Int., in press, published online August 16, 2012.

Revell, VL, Molina, TA, & Eastman, CI. Human phase response curve to intermittent blue light using a commercially available device. J. Physiol. In press, published online July 2, 2012

Smith, MR & Eastman, CI. Shift Work: Health, performance and safety problems, traditional countermeasures and innovative management strategies to reduce circadian misalignment. Nature and Science of Sleep, in press.

Crowley, SJ & Eastman, CI. Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance, Psychopharmacolgy, in press.