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Biological Rhythms Research Laboratory
Behavioral Sciences, Neurological Sciences
Graduate College, Rush Medical College
Biological Rhythms Research Laboratory
1645 W. Jackson Blvd.
Suite 425
Chicago, IL 60612
(312) 563-4787
(312) 563-4900
PhD, Biological Psychology, University of Chicago, 1980

BS, Mathematics, State University of New York at Albany (SUNYA), 1965

Actigraphy, Circadian Phase Assessments
Research Interests

Human Circadian Rhythms (especially effects of bright light and melatonin),Shift Work, Jet Lag.


Principal Investigator

1984 - 1986 Human Circadian Rhythms During a Modified Sleep-Wake Schedule, Rush University Committee on Research; $14,252.

1986 - 1989 Applications of Non-24-Hour Sleep-wake Schedules, NIH, NINDS, R23 NS23421, $98,589 direct costs.

1989 - 1999 Shifting Human Circadian Rhythms with Bright Light, NIH, NINDS, R01 NS23421, about $150,000 direct costs/yr.

1987 - 1997 Mechanisms of Antidepressant Effects of Bright Light (bright light treatment of winter depression), NIH, NIMH, R01 MH42768, about $130,000 direct costs/yr.

1995 - 1996 Shifting Human Circadian Rhythms with Exogenous Melatonin, Rush University Committee on Research, $9,580.

1997 - 2001 Melatonin, Human Circadian Rhythms and Sleep, NIH, NINDS, R01 NS35695, about $150,000 direct costs/yr.

1999 - 2008 Practical Circadian Interventions for Night Shift Work, CDC, NIOSH, R01 OH003954, $250,00 direct costs/yr.

2000 - 2005 Reducing Jet-Lag with Practical Circadian Treatments, NIH, NINR, R01 NR07677, $200,000 direct costs/yr.

2003 - 2007 Effects of Short and Long Nights on the Circadian Clock, NIH, NHLBI, R01 HL072408, $250,000 direct costs/yr.

2006 - 2011 Blue Light and Melatonin for Circadian Rhythm Disorders and Jet Lag, NIH, NINR, R01 NR007677, $225,000 direct costs/yr.

2007 - 2011 Phase Response Curves for Home Remedies to Treat Circadian Misalignment, NIH, NHLBI, R01 HL086934, $250,000 direct costs/yr
2012 - 2017 Racial Differences in Human Circadian Rhythms NIH, NINR, R01 NR007677, Total Cost = $2,705,706

2008 - 2013 Sleep Length and Circadian Regulation in Humans, NIH, NHLBI, R01 HL083971, $250,000 direct costs/yr. Helen Burgess, PI.
2011 - 2014 Circadian Phase Assessments at Home: Validity and Normative Data  NIH, NCCAM, R01 HL105385, Total Cost = $1,139,850. Helen Burgess, P.I.

2012 - 2017 Adolescent Sleep Delay: Circadian Regulation and Phase Shifting with Light NIH, NHLBI, R01 HL105395, Total Cost = 2,059,437. Stephanie Crowley, P.I.

Selected Publications

Crowley, SJ, Lee, C, Tseng, CY, Fogg, LF & Eastman, CI. Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. J. Biol. Rhythms, 18: 513-523, 2003.

Burgess, HJ & Eastman, CI. Short nights attenuate light-induced circadian phase advances in humans. J. Clin Endocrinol. Metab., 90: 4437-4440, 2005.

Revell, VL & Eastman, CI. How to trick Mother Nature into letting you fly around or stay up all night. J. Biol. Rhythms, 20: 353-365, 2005.

Revell, VR, Burgess, HJ, Gazda, CJ, Smith, MR, Fogg, LF & Eastman, CI. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J. Clin. Endocrinol. Metab., 91: 54-59, 2006.

Burgess, HJ, Revell, VL, Eastman, CI, A three pulse phase response curve to three milligrams of melatonin in humans. J. Physiol. 586.2: 639-647, 2008.

Burgess, HJ & Eastman, CI. Human tau in an ultradian light-dark cycle. J. Biol. Rhythms, 23 (4): 374-376, 2008.

Eastman, CI & Burgess, HJ. How to travel the world without jet lag. Sleep Medicine Clinics, 4: 241-255, 2009.

Smith, MR, Fogg, LF. & Eastman, CI. A compromise circadian phase position for permanent night work improves mood, fatigue, and performance. Sleep, 32(11): 1481-1489, 2009.

Smith, MR, Burgess, HJ, Fogg, LF & Eastman, CI. Racial differences in the human endogenous circadian period. PLoS ONE 4(6): e6014, 2009. doi:10.1371/journal.pone.0006014, 2009.

Burgess, HJ, Revell, VL, Molina, TA & Eastman CI. Human phase response curves to three days of daily melatonin : 0.5 mg versus 3.0 mg. J. Clin. Endocrinol. Metab, 95(7):3325-3331, 2010.

Eastman, CI. How to get a bigger dose of bright light: A Commentary on Dewan et al. Light-induced changes of the circadian clock of humans: it is more effective to increase duration than light intensity. Sleep, 34 (5): 559-560, 2011. PMID:21532946, PMCID:PMC3079932

Revell, VL & Eastman, CI. Jet lag and its prevention, Chapter 30, pages 390-401, in Therapy in Sleep Medicine, Editors: Barkoukis, T.J., Matheson, J.K., Ferber, R. & Doghramji, K., Elsevier, 2012.

Eastman, CI, Molina, TA, Dziepak, ME & Smith, MR.  Blacks (African Americans) have shorter free-running circadian periods than Whites (Caucasian Americans).  Chronobiol. Int., 29 (8): 1072-1077, 2012.  PMID:22894720, PMCID:PMC3454515.

Revell, VL, Molina, TA, & Eastman, CI. Human phase response curve to intermittent blue light using a commercially available device.  J. Physiol. 590 (19): 4859-4868, 2012.  PMID: 22753544, PMCID: PMC3487041.

Smith, MR & Eastman, CI.  Shift Work: Health, performance and safety problems, traditional countermeasures and innovative management strategies to reduce circadian misalignment.  Nature and Science of Sleep, 4: 111-132, 2012. PMID: 23620685 PMCID: PMC3630978.

Crowley, SJ & Eastman, CI.  Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance, Psychopharmacology, 225:825-837, 2013, published online Sept 22, 2012, PMID:23001190, PMCID:PMC3558560.


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