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Cs-Szabo
Gabriella
PhD
Biochemistry, Orthopedic Surgery
Graduate College, Rush Medical College
1735 W. Harrison St.
Cohn Research Building
Ste. 514
Chicago, IL 60612

1735 W. Harrison St.
Cohn Research Building
Ste. 563A
Chicago, IL 60612

(312) 942-2225
(312) 942-3053
gabriella_cs-szabo@rush.edu

Research Interests

Gabriella Cs-Szabo, PhD, has a primary appointment as associate professor of biochemistry, with a secondary appointment as associate professor of orthopedic surgery. She has a PhD in biochemistry from the University of Debrecen, Medical School, Hungary. She accepted an invitation to join the Department of Biochemistry at Rush Medical College at Rush University Medical Center in 1992.

Cs-Szabo's research focuses on a group of extracellular matrix components known as the small proteoglycans: biglycan, decorin, fibromodulin and lumican. Small proteoglycans may play a role in the development of osteoarthritis, and are possibly involved in the repair processes that accompany the disease. The studies focus on the regulation of their expression, fragmentation and alternative exon splicing of these molecules, as well as the effects of these molecules upon the chondrocytes and the assembly of the matrix. The interplay of small proteoglycans and growth factors is also under investigation to understand their physiological importance during tissue development and repair. These approaches provide a better understanding of the in vivo function of the small proteoglycans in the matrix of the articular cartilage.

A second major research endeavor of this laboratory, in collaboration with Drs. E. Thonar and K. Masuda, is to investigate the possibility of growing cartilage tissue in vitro from cells of different cartilage sources. Ultimately, through biochemical and molecular biology manipulations, the tissue produced would show features of the normal articular cartilage and the information gained could be potentially used to change the osteoarthritic chondrocytes to normal phenotype.

Another major interest of this research group (in collaboration with the investigators of the Department of Orthopedic Surgery) is to understand the biology of intervertebral disc degeneration in the lumbar spine. The ultimate goal of this effort is to identify the major players that are responsible for intervertebral disc degeneration, and to investigate the possibility of interfering with and/or reversing the degeneration process.

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