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Mulshine
James
L.
MD
Professor
Associate Provost for Research and Vice President
Director, Rush Translational Sciences Consortium
Internal Medicine
Rush Medical College, Rush University
1735 W. Harrison St.
Cohn Research Building
Ste. 206
Chicago, IL 60612-3823
(312) 942-3589
(312) 563-3377
james_l_mulshine@rush.edu
MD, Loyola Stritch School of Medicine, 1977

BA, College of the Holy Cross, 1974

Biological Phenomena Cell Phenomena and Immunity, Neoplasms
Elisa/Plate reading, Imaging Techonology, Immunohisto-/immunocytochemistry, In Situ Hybridization, PCR, Real-time PCR, si RNA, Western Northern Southern Blotting


Research Interests

Mulshine's research involves translating basic science into meaningful tools for cancer management, especially for lung cancer management. He has been awarded a number of United States and international patents. His research productivity has been recognized with awards from the Department of Commerce, the Public Health Service, the NIH, and the NCI. He is on numerous editorial and foundation boards involved with lung cancer and prevention research. Mulshine is also a visiting professor at the University of Tokyo Medical University Clinical Proteome Center. Mulshine has worked extensively with academia as well as with industry through collaborative research and development agreements to move cancer management tools into broader clinical application.

In addition to his research activities, Mulshine has had senior administrative responsibilities, such as chairing the NCI's intramural investigational review board and has been the NCI's representative to the NIH's Cooperative Research and development subcommittee. In addition, he co-chairs the upper aerodigestive research faculty in the Center for Cancer Research and is the head of the intervention section in the cell and cancer biology branch of the Center for Cancer Research, NCI. His research has been in developing integrated cancer detection and intervention strategies based on tumor biology. His research has identified particular arachidonic acid metabolites as key factors in promoting upper aerodigestive carcinogenesis. A particular focus is on cancer at a stage of interepithelial neoplasia (IEN), as this is a particularly attractive stage to define safe and effective new treatment strategies. A recently completed randomized, placebo control of a locally delivery cyclooxygenase inhibitor for oral leukoplakia is an example of this approach. He has also extensively published on efforts to develop effective new diagnostic approaches for early epithelial lung cancer and developing complementary tailored approaches to drug delivery to arrest progression or reverse early carcinogenesis. He is currently working on improving the management of spiral CT detected lung cancer in high risk populations.

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