|Last Name: ||Landay|
|First Name: ||Alan|
|M. I.: ||L. |
|Degree & Certifications: ||PhD|
|Endowed Professorship: ||The Thomas J. Coogan, Sr., MD, Professor|
|Rank & Title: ||Professor |
Facilitator, Flow Cytometry
|College: ||GME, Graduate College, Rush Medical College|
|Office Location: ||1735 W. Harrison St.|
Cohn Research Building
Chicago, IL 60612-3823
|Laboratory Location: ||1735 W. Harrison St.|
Cohn Research Building
Chicago, IL 60612-3823
|Phone: ||(312) 942-2849|
|Fax: ||(312) 942-2808|
|Education: ||PhD, University of Pittsburgh, 1981|
BS, Pennsylvania State University, 1976
|Research Areas: ||Biological Phenomena Cell Phenomena and Immunity, Immune System Diseases, Virus Diseases|
|Laboratory Techniques: ||Cytokine Assessment, Flow Cytometry|
|Faculty/Staff Description: ||
Landay A, Benning L, Bremer J, Weiser B, Burger H, Nowicki M, and Kovacs, A. Correlates of immune activation marker chanes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs. J Infect Dis 188:209-18, 2003.
Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood 102(6), 2003.
Kemal KS, Foley B, Burger H, Anastos K, Minkoff H, Kitchen C, Philpott SM, Gao W, Robison E, Holman S, Dehner C, Beck S, Meyer III, W, Landay A, Kovacs A, Bremer J and Weiser B. HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation. PNAS 100(22):12972-12977, 2003.
Spritzler J, Mildvan D, Russo A, Asthana D, Livnat D, Schock B, Kagan J, Landay A, and Haas DW. Can immune markers predict subsequent discordance between immunologic and virologic responses to antiretroviral theapy? - Adult AIDS Clinical Trials Group. Clin Inf Disease 37:551-8, 2003.
Weber J, Rangel HR, Chakraborty B, Marotta ML, Valdez H, Fransen K, Florence E, Connick E, Smith KY, Colebunders RL, Landay A, Kuritzkes DR, Lederman MM, Vanham G, Quinones-Mateu ME. Role of baseline pol genotype in HIV-1 fitness evolution. J Acquir Immune Defic Syndr. 33(4):448-460, 2003.
Landay AL, Spritzler J, Kessler H, Mildvan D, Pu M, Fox L, O'Neil D, Schock B, Kuritzkes D, and Lederman MM for the ACTG 5014 Team. Immune reconstitution is comparable in antiretroviral (ARV) na?ve subjects following 1 year of successful therapy with a nucleoside reverse transcriptase inhibitor (NRTI) or protease inhibitor (PI) containing ARV regimen. Jour Inf Dis 188:1444-54, 2003.
Haas DW, Wu H, Li H, Bosch R, Lederman MM, Kuritzkes D, Landay A, Connick E, Benson C, Wilkinson G, Kessler H and Kim R. MDR1 gene polymorphisms and phase-1 viral decay during HIV-1 infection - An AACTG study. JAIDS 34:295-8, 2003.
Tenorio AR, Smith KY, Kuritzkes D, Young R, Bremer J, Wrin T, Pepropoulos C, Shott S, Landay A, Kessler HA. HIV-1 infected antiretroviral-treated patients with prolonged partial viral suppression: Clinical, virologic and immunologic course. JAIDS 34(5):491-496, 2003.
Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neill D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC, Jr., Glesby MJ, and the National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma HIV RNA and CD4 lymphocyte counts in patients with uncontrolled HIV infection. J Infec Dis 188:1804-14, 2003.
Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinksky SM, Zack JA. Public Health. A sound rationale needed for phase III HIV-1 vaccine trials. Science 303(5656):316, 2004.
Al-Harthi L, Voris J, Patterson BK, Becker S, Eron J, Smith KY, Mildvan D, D'Amico R, Snidow J, Pobiner B, Yau L, Landay A. Evaluation of immune reconstitution parameters in antiretroviral naive patients: Role of the thymus in immune recovery. HIV Medicine 5(1):55-65, 2004.
Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM. Proliferation responses to HIV p24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS 18(4):605-13, 2004.
Mildvan D, Bosch R, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A. Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response. J Infec Dis 189(10):1811-20, 2004.
Winchester R, Pitt J, Magder LS, Goring HH, Landay A. Mother-to-Child Transmission of HIV-1: Strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms. J Acquir Immune Defic Syndr 36(2):659-670, 2004.
Bahbouhi B, Landay A and Al-Harthi L. Dynamics of cytokine expression within HIV productively infected primary CD4+ T cells. Blood 103(12):4581-7, 2004.
Lurain NS, Robert ES, Xu J, Camarca M, Landay A, Kovacs AA, Reichelderfer PS. Human immunodeficiency virus type 1 and cytomegalovirus co-infection in the female genital tract. J Infec Dis 190(3):619-23, 2004.
Smith K, Aga E, Bosch RJ, Valdez H, Connick E, Landay A, Kuritzkes D, Gross BH, Francis IR, McCune JM, Kessler H, Lederman M. Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy. AIDS 18(14):1953-56, 2004.
Nag P, Kim J, Sapiega V, Landay AL, Bremer JW, Mestecky J, Reichelderfer P, Kovacs A, Cohn J, Weiser B, Baum LL. Women with cervicovaginal antibody dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA loads. J Infec Dis. 190(11):1970-8, 2004.
Managlia E, Landay A and Al-Harthi L. Interleukin (IL)-7 induces antigen-independent priming of naive CD4+ T cells without altering their classical naive phenotype expression. Immunology 1149:322-35, 2005.
Lambert JS, Moye J Jr., Plaeger SF, Stiehm ER, Bethel J, Mofenson LM, Mathieson B, Kagan J, Rosenblatt H, Paxton H, Suter H, Landay A. Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal HIV transmission and infant infection. Clin Diag Lab Immunol 12:622-631, 2005.
Baird H, Marozsan AJ, Lederman MM, Landay A, Mildvan D, Kuritzkes DR, Kessler HA and Arts EJ. Monitoring processed, mature human immunodeficiency virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen. AIDS Res Ther 2:2, 2005.
Spear GT, Alves M, Cohen M, Bremer J and Landay AL. Relationship of HIV RNA and cytokines in saliva and plasma from HIV-infected persons. FEMS Immunology and Medical Microbiology 45(2):129-36, 2005.
Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366(9485):549-55, 2005.
Kalayjian RC, Spritzler J, Pu M, Landay A, Pollard RB, Stocker V, Al-Harthi L, Gross BH, Francis IR, Fiscus SA, Tebas P, Bosch RJ, Valcour V, Lederman MM for the Adult AIDS Clinical Trials 5015 and 5113 Protocol Teams. Distinct mechanisms of T-cell reconstitution can be identified by estimating thymic volume in adult HIV-1 disease. J Infec Dis 192(9):1577-87, 2005.
Donoval BA, Landay AL, Bailey RC. HIV-1 target cells in foreskin of African men with varying histories of sexually transmitted infections. Am J Clin Pathol 125:386-391, 2006.
Al-Harthi L, Voris J, Du W, Wright D, Nowicki M, Landay A, Kovacs A. Evaluating the impact of Hepatitis C Virus (HCV) on Highly Active Antiretroviral Therapy-Mediated Immune Responses in HCV/HIV-Coinfected Women: Role of HCV on Expression of Primed/Memory T Cells. J Infec Dis 193(9):1202-10, 2006.
Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cells (NFAT)-dependent pathway. Virology, March 14, 2006.
Goicocchea M, Smith D, Landay A, Tenorio A, May S, Lin L, Haubrich R. Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: Association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infec Dis 194:29-37, 2006.
Ruitenberg JJ, Mulder CB, Maino V, Landay AL, Ghanekar SA. Equivalent performance of VACUTAINER CPT and ficoll density gradient separation perform equivalently in maintaining the quality and function of PBMC from HIV seropositive blood samples. BMC Immunol 7:11, 2006.
Montoya CJ, Jie H-B, Al-Harthi L, Mulder C, Patino PJ, Rueles MT, Krieg A, Landay AL, Wilson SB. Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. J Immunol 177:1028-1039, 2006.
Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Nanan R, Kelleher A, Fazekas de St Groth B. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203(7):1693-700, 2006.
Montoya CJ, Velilla PA, Chougnet C, Landay AL, Rugeles MT. Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals. Clin Immunol 120(2):138-46, 2006.
Haas DW, Geraghty D, Andersen J, Mar J, Motsinger AA, D'Aquila R, Unutmaz D, Benson C, Ritchie M, Landay A. Immunogenetics of CD4 lymphocyte recovery during antiretroviral therapy: An Adult AIDS Clinical Trials Group Study. J Infec Dis 194:1098-1107, 2006.
Kim J, Nag P, Landay A, Alves M, Cohen M, Bremer J, Baum L. Saliva can mediate HIV-1 specific antibody dependent cell-mediated cytotoxicity. FEMS Immunology & Medical Microbiology 48:267-273, 2006.
Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A, Grey P, Fillayson R, Kaldor J, Rosenberg ES, Walker BD, Fazekas de St Groth B, Cooper DA and Kelleher AD on behalf of the PHAEDRA Study Team. Infection of CD127+ (Interleukin-7 Receptor+) CD4+ cells and overexpression of CLA-4 T cells during primary human immunodeficiency virus type I infection. Jour of Virol 80(20):10162-10172, 2006.