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The Graduate College > Pharmacology > Pharmacology Research > Pharmacology Faculty Research Summaries
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  • The laboratory of Dr. Paul Carvey examines the pharmacology of the dopamine system in the brain with particular interest in Parkinson's disease. Using both in vitro and in vivo models he is currently looking at the role of the blood-brain barrier (BBB) as it relates to the entry of environmental toxins as well its relationship to peripheral immune cell involvement of disease progression.

  • The laboratory of Dr. Bill Hendey examines how early stages of neutrophil apoptosis affect neutrophil response to inflammation. Other interests include how inflammation contributes to neurodegenerative diseases.

  • The laboratory of Dr. Judith Luborsky examines immune responses in ovarian autoimmune disease and ovarian cancer in humans and in an animal model with a focus on early events and early detection. Dr Luborsky is also director of the Proteomics Core Research Facility at Rush University.

  • The laboratory of Dr. Hazel Lum?works in the broad area of mechanisms of vascular inflammatory injury, which underlies a wide range of disease conditions such as atherosclerosis, lung injury, diabetes, and neuronal disorders. In these conditions, the vascular endothelium is abnormal, presenting with increased permeability, enhanced adhesion for circulating leukocytes, high metabolic activity, increased proliferation potential, and elevated secretion of mediators, all of which could lead to inflammatory injury and ultimately organ failure.

  • The laboratory of Dr. Celeste Napier examines changes in the adult mammalian brain that alter motivative behaviors, including those associated with drug addiction. Dr. Napier is also director of the Research and Recovery Center for Compulsive Behaviors and Addiction.
  • The laboratory of Dr. John Somberg examines cardiovascular pharmacology with specific interest in drugs that affect the rapid potassium channel (IKr). Interests also include chiral separation of drugs and how this effects drug action and the role of the nervous system in facilitating cardiac arrhythmias.

  • The laboratory of Dr. Xiu-Ti Hu examines the cellular mechanism of cocaine withdrawal, which is associated with the chronic cocaine-induced neuroadaptations in voltage-gated ion channel function and signaling in the mesocorticolimbic system (known as the reward pathway), particularly in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc).

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