Orthopedic Device Retrieval, Tissue Collection
This resource provides material for research studies of the implants by Rush University Medical Center (RUMC) investigators under specific Investigational Review Board-approved protocols. Each year, more than 500 additional components are added to the repository. The components become available either through revision arthroplasty or postmortem retrieval. They are procured, processed to reduce biological hazards, packaged, cataloged and stored by implant type. Thus, large numbers of components of a specific or similar design are made readily available for examination by both academic and industrial researchers. Information from this repository contributes to improved device design and is used to address safety issues such as polyethylene particle wear, metal ion lost, and local and systemic inflammatory responses.
Biocorrosion Laboratory for the Study of Orthopedic Implant-Related Particle and Heavy Metal-Ion Biology Core
Directors Joshua Jacobs, MD, and Robert Urban, PhD, and co-director, Laura Quigley, RN. This highly specialized laboratory has a clean room to generate metal and plastic particles of controlled size. This resource can be used to characterize the physical and biologic properties of the micron and submicron particles, analyze low levels of trace metals in bone and soft tissues and allow understanding of the nature of joint prosthesis failure.