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Research at Rush > Core Research Resources > miRNA and Gene Expression > miRNA and Gene Expression Core
About Rush University
The microRNA and Gene Expression Core is intended to facilitate research on the molecular pathogenesis of disease leading to drug target development, molecular diagnosis, and molecular monitoring of treatment efficacy. MRGEC is equipped with the Applied Biosystems HT7900 RT-PCR, which accommodates 384- and 96 well plates and has fully robotic automatic loading capability. DataAssist data analysis software is used. Supporting apparatus such as a NanoDrop DNA/RNA/protein spectrophotometer and a full range of electrophoresis equipment, together with the BioRad GelDoc XR gel analysis and documentation system, are also available.
The services provided by MRGEC covers all aspects of miRNA and gene expression analysis, from DNA/RNA/miRNA preparation, to microarray miRNA and gene profiling, functional annotation analysis, and validation studies. It facilitates research at all levels, from clinical diagnostic studies to cutting-edge basic, discovery research. 
The MRGEC facilitator and staff provide consultations to help researchers, especially newcomers to genetics and molecular biology studies. The spectrum of support ranges from investigator training in operation and troubleshooting of the apparatus to experimental design/optimization. MRGEC encourages collaborations with researchers, and will provide support to researchers during their grant application and help enhance their grant components of miRNA and gene expression studies. Core also provides data analysis for the Affymetrix /Luminex Gene chip platform using Bio-conductor (NCBI) or R statistical program. Most of the NCBI tools for genomic data analysis are installed, including several Blast programs and sequence retrieval/analysis programs.

Dr Chunxiang "Kevin" Zhang, MD, PhD – Director
Phone: (312) 942-7837

Seby Edassery –Lab Manager
Phone: (312) 563-2628

453  Cohn Research Bldg.
1735 W. Harrison St.
Chicago, IL 60612
Phone: (312) 563-2628 

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