Pharmacology: Course Descriptions

PHR-501 Medical Pharmacology I
Introduction to the basic concepts which describe drug actions. The autonomic nervous system and related drug actions, anti-inflammatory drugs, autacoids, neuropharmacology, psychopharmacology, and anesthetic/analgesic pharmacology. Prerequisites: Permission of instructor. [5]

PHR-502 Medical Pharmacology II
Cardiovascular, diuretic and respiratory agents, hypoglycemic agents, drugs acting on the blood and blood-forming organs, toxicology, antibiotics and cancer chemotherapeutic agents. Prerequisite: PHR-501. [4]

PHR-505 Introduction to Physiology and Pharmacology II Continuation of topics included in PHR-504 [2]

PHR-506 Introduction to Physiology and Pharmacology III Continuation of topics included in 504 and 505. [2]

PHR-521 Laboratory Instrumentation
Course covers principles and applications of experimental equipment. Instrumentation includes: ultraviolet and visible Spectrophotometry, Spectrophotofluorometry, thin-layer chromatography, column chromatography, high pressure liquid chromatography, atomic absorption, liquid scintillation spectrometry, isotope use and handling, pH adjustment, sample weighing, melting point determination, hematocrit determination, centrifugation, and glassware cleaning. [2]

PHR-523 Readings in Clinical Research
This course consists of seminars evaluating clinical research studies in the literature. Each seminar will evaluate a clinical study, its attributes, as well as the methodological problems. Many of the studies discussed will have been undertaken by Rush Clinical Investigators and one of the investigators will lead the discussion.

PHR-542 Pharmacotherapeutics
The use of drugs in the diagnosis, prevention, and treatment of disease is presented with special emphasis in clinical pharmacology. SP [1-6 credits]

PHR-551 Ethics in Biomedical Research and the IRB
This course provides the framework around which clinical research projects are based in terms of the Institutional Review Board. The course includes didactic lectures on the legal requirements of informed consent, regulatory processes, intellectual property, the role of the office research integrity as well as required participation on IRB review panels inside the University. [2]

PHR-552 Introduction to the Regulatory Process: Drug Discovery and Development
Lectures cover drug discovery, the U.S. regulatory process including IND and NDA and clinical trials I through IV. The course also includes lectures on drug metabolism, principles of toxicity, adverse drug reaction reporting, the IRB responsibilities of investigators, biologic and generic drug development, PK/PD modeling, orphan drug development, and medical device approval. [3]

PHR-556 Tools for Research
This course focuses on the practical elements required to work as a scientist in modern times. It includes didactic lecture and computer practice on Power Point, poster making, importing into word documents, Adobe Photoshop, Sigma Plot, Grants.org, on line proposal submission, advanced med-line searches, Excel spreadsheets, and reference managing systems. [2]

PHR-559 Readings in Special Populations
This course covers issues relating in doing clinical research with Special Populations. The course is a seminar discussion of these issues, when research is undertaken in populations of prisoners, the elderly, the mentally retarded, emergency situations, minority groups, as well as other groups considered special populations.

PHR-561 Drug Biotransformation and Pharmacogenetics
The various types of biotransformation reactions, including all Phase I and Phase II reactions are discussed in detail. The course describes in detail the biochemistry of drug inactivation both in the liver and at extrahepatic sites and the effects of genotype on that biotransformation. Additional topics to be discussed include prodrugs and protoxins and special considerations needed when discussing the CNS, other separated compartments (e.g., certain tumors and bladder), and the influence of age, gender, hepatic induction, kidney failure, and genetic phenotypes. [3]

PHR-562 Toxicology/Drug to Drug Interaction/Poisoning
This course will cover principles of toxicology and in depth special issues relating to drug overdose, heavy metal poisoning, prescription drug side effects, natural and OTC poisoning, as well as their treatment procedures. The role of poison control center triage of cases, ER treatment, suicide management and unique considerations therein, and characteristic toxic profiles of drug classes will be described. Medico-legal issues associated with toxicology will also be discussed. [3]

PHR-568 Advanced Pharmacokinetics
This course will describe in detail the derivation and theory of pharmacokinetics. This course picks up where the general survey course given in PHR-501 leaves off and describes the mathematical constructs behind PK measures as well as in depth discussion of two and multicompartment models. Upon completion of this course the trainee will be able to design and analyze results from a Phase I and II trials involving a drug acting in two compartments. [2]

PHR-573 Readings in Drug Abuse and Addiction
The literature on drug abuse will be surveyed. Areas of emphasis will include the role of DA in addiction, the concept of the addictive personality and the genetics of addiction, the neurobiology of incentive salience, dissociation of tolerance from euphorogenic effects, history of addiction theory, and the unique aspects of various drugs of abuse. The ethics of chronic pain management in the clinical setting will also be discussed. [1]

PHR-585 Clinical Pharmacology Research
This survey course describes in detail all aspects of performing clinical drug trials. It includes extensive discussion on IND applications, how drug studies differ from other types of studies, GLP certification procedures, informed consent procedures involving drugs, the characteristics of Phase I-IV studies and the special considerations involved with each, packaging and delivery considerations, role of the pharmacokineticist in the design and implementation of these studies, sample and data collection procedures, FDA oversight considerations, data analysis and interpretation, and laboratory responsibilities after the study is completed. [3]

PHR-590 Special Topics in Pharmacology
The course is designed to allow the student flexibility in independently pursuing a particular area of interest. May be taken for one or more terms. [variable hours]

PHR-593 Introduction to Grantsmanship
This course is designed to provide the practical aspects of proposal submission. In addition to covering basic writing skills, it addresses specific elements that should be included in each of the various sections of federal grants, foundation applications, and biotech contracts. In addition, it talks about ways of identifying sources for funding, a survey of the NIH landscape and how to prepare budgets. The online submission process is also reviewed. [2]

PHR-594 Advanced Receptor Pharmacology This courses covers the various receptor subtypes with an emphasis on receptor activation and signaling and how such processes ultimately effect drug action [3]

PHR-595 Clinical Pharmacology/Commercial Practicum
This practicum involves actual patient contact time in the clinical pharmacology units within Rush as well as the Chicagoland area. The practice is designed to expose the clinical scientist to the practical aspects of conducting clinical pharmacology research in both an academic and commercial setting. Seminars on recruitment procedures, study coordinators, specialty needs, and dealing with special populations will be provided. [2]

PHR-597 Clinical Pharmacology Thesis Research
A minimum of 8 research hours must be completed. This will involve actual time collecting data in a clinical pharmacology study either as part of an individual's own project or in collaboration with a mentor. As part of the requirements of this research, the investigator will have to either write an IND or a drug company research proposal as well as complete a written thesis and defend it publicly. [variable hours/quarter]

PHR-598 Research in Pharmacology
Laboratory research in an area of interest that will form the basis of a dissertation proposal or a master's thesis. These research hrs are taken prior to passage of comprehensive exams. By special arrangement. [variable hours/quarter]

PHR-622 Experimental Models in Pharmacology
Advanced laboratory courses focuses on techniques used in preparing experimental methods/models for research. By arrangement only. [1-3]

PHR-691 Pharmacology Seminar
A pharmacology seminar series featuring speakers from outside and within the department. Students are required to make presentations a minimum of once a year. [1] 

PHR-699 Dissertation Research
Laboratory research for the doctoral dissertation for PhD candidates only. By special arrangement. [variable hours]